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首页> 外文期刊>Journal of experimental & clinical cancer research : >Antimutagenicity of herbal detoxification formula Smoke Shield against environmental mutagens.
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Antimutagenicity of herbal detoxification formula Smoke Shield against environmental mutagens.

机译：草药排毒配方烟盾针对环境诱变剂的抗突变性。

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Smoke Shield is a formulation designed to reduce smoke related mutagenicity and toxicity in the population. Smoke Shield contains a dual extract of turmeric (Curcuma longa) obtained by supercritical CO2 gas extraction and post-supercritical hydroethanolic extraction together with extracts of green tea and other spices, whose presence synergistically increases the activity of turmeric. In the present study we have shown its antimutagenic activity to various environmental mutagens in vitro and in vivo. Smoke Shield was found to produce significant inhibition of mutagenicity to Salmonella typhimurium induced by sodium azide and 4-nitro-0-phenylenediamine (NPD) at a concentration of 2 mg/plate while inhibition to N-methyl-N-nitro N'nitrosoguanidine was less significant. Inhibition was also found to depend upon the strain which was used. Smoke Shield was found to be more effective against mutagens needing metabolic activation such as 2-Acetamidofluorene (2-AAF) and benzo[a]pyrene. Smoke Shield was also found to significantly inhibit the mutagenicity induced by tobacco extract to Salmonella typhimurium TA102. Smoke Shield was also found to inhibit the urinary mutagenicity of rats treated with the benzo[a]pyrene and tobacco extract. Moreover, Smoke Shield administration was found to inhibit the urinary mutagenicity in smokers. These results indicate that Smoke Shield could inhibit mutagenic response in vitro and in vivo produced by several kinds of mutagens present in our atmosphere.
机译：Smoke Shield是一种旨在减少人群中与烟雾相关的诱变性和毒性的配方。 Smoke Shield包含一种姜黄双重提取物（姜黄），该提取物是通过超临界CO2气体提取和超临界后氢乙醇提取而获得的，以及绿茶和其他香料的提取物，其协同作用可提高姜黄的活性。在本研究中，我们已经显示了其在体外和体内对各种环境诱变剂的抗诱变活性。发现Smoke Shield对叠氮钠和4-硝基-0-苯二胺（NPD）诱导的鼠伤寒沙门氏菌的致突变性具有明显的抑制作用，浓度为2 mg /板，而对N-甲基-N-硝基N'亚硝基胍的抑制作用为不那么重要。还发现抑制作用取决于所使用的菌株。发现烟盾对需要代谢活化的诱变剂（例如2-乙酰氨基芴（2-AAF）和苯并[a] py）更有效。还发现，Smoke Shield可显着抑制烟草提取物对鼠伤寒沙门氏菌TA102的诱变性。还发现，Smoke Shield可抑制用苯并[a] and和烟草提取物治疗的大鼠的尿液致突变性。此外，发现吸烟盾可以抑制吸烟者的尿致突变性。这些结果表明，Smoke Shield可以抑制我们大气中存在的几种诱变剂在体外和体内产生的诱变反应。

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