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首页> 外文期刊>Journal of experimental & clinical cancer research : >An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer.
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An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer.

机译：基质金属蛋白酶1启动子基因多态性与乳腺癌的淋巴结转移之间的关联。

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摘要

A single guanine insertion (1G/2G polymorphism) in the promoter of the matrix metalloproteinase (MMP-1) gene creates a binding site for the transcription factor and may affect the level of transcription of MMP-1. An elevated level of MMP-1 in cancer cells may facilitate their invasion and contribute to metastasis. To evaluate the contribution of 1G/2G polymorphism in the development and/or progression of breast cancer we genotyped 135 subjects with breast cancer. The 1G/2G polymorphism was determined by the method based on restriction endonuclease digestion. We found that the frequency of the 2G allele was higher in lymphnode-metastasis patients than in the group without metastasis (p < 0.001). We did not find differences between distribution of the genotypes and frequencies of alleles in cancer patients and in healthy subjects served as control. Our results suggest that allele 2G may be associated with lymphnode metastasis in patients with breast cancer and therefore it can be considered as a prognostic marker in this disease.
机译：基质金属蛋白酶（MMP-1）基因启动子中单个鸟嘌呤插入（1G / 2G多态性）为转录因子形成结合位点，并可能影响MMP-1的转录水平。癌细胞中MMP-1水平升高可能会促进其侵袭并促进转移。为了评估1G / 2G多态性在乳腺癌发展和/或进展中的作用，我们对135名乳腺癌患者进行了基因分型。通过基于限制性内切核酸酶消化的方法确定1G / 2G多态性。我们发现，淋巴结转移患者中2G等位基因的频率高于无转移的患者（p <0.001）。我们没有发现在癌症患者和作为对照的健康受试者中等位基因的基因型分布和频率之间存在差异。我们的结果表明，等位基因2G可能与乳腺癌患者的淋巴结转移有关，因此可以将其视为该疾病的预后指标。

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