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首页> 外文期刊>Journal of experimental & clinical cancer research : >Novel DNA amplification on chromosomes 6q23-24 and 4p15.2 in breast cancer identified by arbitrarily primed polymerase chain reaction.
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Novel DNA amplification on chromosomes 6q23-24 and 4p15.2 in breast cancer identified by arbitrarily primed polymerase chain reaction.

机译：通过任意引发的聚合酶链反应鉴定了乳腺癌6q23-24和4p15.2染色体上的新型DNA扩增。

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摘要

Breast cancer is the most common cancer among women worldwide. The molecular basis of breast cancer has not yet been fully elucidated. In this report, novel DNA amplification on chromosomes 6q23-24 and 4p15.2 were identified by arbitrarily primed polymerase chain reaction, gene cloning, nucleotide sequencing and identified by comparison with known sequences in genome data base, and quantitated by real-time PCR. Results revealed that 25 of 32 (78.1%) breast cancer cases harbored DNA amplification on chromosomes 6q23-24 and 4p15.2. There was a significant association between increase in tumor size (> 3cm) and DNA amplification on chromosome 6q23-24 (Odds ratio = 13.75, 95% CI = 1.26-350.38, P 0.018). The results indicated that DNA amplification on chromosome 6q23-24 may be involved in the progression of breast cancer.
机译：乳腺癌是全世界女性中最常见的癌症。乳腺癌的分子基础尚未完全阐明。在本报告中，通过任意引发的聚合酶链反应，基因克隆，核苷酸测序鉴定了6q23-24和4p15.2染色体上的新型DNA扩增，并与基因组数据库中的已知序列进行了比较，并通过实时PCR进行了定量。结果显示，在32个乳腺癌病例中，有25个（78.1％）在6q23-24和4p15.2染色体上具有DNA扩增。肿瘤大小的增加（> 3cm）与染色体6q23-24上的DNA扩增之间存在显着相关性（几率= 13.75，95％CI = 1.26-350.38，P = 0.018）。结果表明，染色体6q23-24上的DNA扩增可能与乳腺癌的进展有关。

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