• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of experimental & clinical cancer research : >Single fraction partial breast irradiation in prone position.
【24h】

Single fraction partial breast irradiation in prone position.

机译：俯卧位单部分乳腺照射。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this work is to introduce a new treatment approach and technique for partial breast irradiation in only one session to patients in prone position by using a dedicated positioning device. The patients were treated on a home-made treatment table top that allows the breast to hang down. A particular immobilization system was introduced in order to assure the reproducibility of patient positioning between the CT acquisition session and the treatment session. The clinical target volume (CTV) was outlined according to surgical clips position and/or tumor location on preoperative mammography. Because of negligible movement due to respiration, only an additional margin of 3 mm was added to obtain the planning target volume (PTV). Based on radiobiological calculations, a dose of 21 Gy was prescribed to PTV. The tumor bed was treated with 3D-CRT technique by using 5 fields and rotating the table while the gantry was approximately 90 or 270 degrees. Thirty patients were enrolled for this study chosen in conformity to an approved clinical protocol. The average percentage of PTV volume enclosed in the 90% and 95% of prescribed dose were 99.9 and 98.6% respectively, while only 3.4% of PTV volume received more than 105% of prescribed dose. Dose to 3% of skin volume was, on average, 15.2 Gy. In 97% of patients, less than 50% of the ipsilateral breast received a dose greater than half the prescribed dose. Mean doses to lungs, heart and contralateral breast were negligible. With a median follow-up of 9 months, no important early toxicity was observed both for skin and breast tissue. The treatment of breast tumor bed in prone position in only one session by using the 3D-CRT is technically feasible and seems to be a promising alternative to other accelerated partial breast irradiation techniques.
机译：这项工作的目的是介绍一种新的治疗方法和技术，通过使用专用的定位设备，仅在一个疗程中向处于俯卧位的患者提供部分乳房照射。患者在自制的治疗台上进行了治疗，使乳房垂下。为了确保在CT采集阶段和治疗阶段之间患者定位的可重复性，引入了一种特殊的固定系统。根据术前乳房X线照片上的手术夹位置和/或肿瘤位置概述了临床目标体积（CTV）。由于呼吸引起的运动可忽略不计，因此仅增加了3毫米的余量来获得计划目标体积（PTV）。根据放射生物学计算，PTV的剂量为21 Gy。用3D-CRT技术治疗肿瘤床，使用5个视野并在台架大约为90或270度时旋转工作台。根据批准的临床方案，选择了30名患者参加了本研究。规定剂量的90％和95％中封装的PTV体积的平均百分比分别为99.9和98.6％，而只有3.4％的PTV体积接收的剂量大于105％。占皮肤体积的3％的剂量平均为15.2 Gy。在97％的患者中，不到50％的同侧乳房接受的剂量大于处方剂量的一半。肺，心脏和对侧乳房的平均剂量微不足道。中位随访9个月，对皮肤和乳房组织均未观察到重要的早期毒性。使用3D-CRT仅在一个疗程中俯卧位乳腺肿瘤床的治疗在技术上是可行的，并且似乎是其他加速的局部乳房照射技术的有希望的替代方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号