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首页> 外文期刊>Journal of experimental & clinical cancer research : >Urine calcium and deoxypyridinoline in assessment of response to local radiation therapy for metastatic bone disease.
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Urine calcium and deoxypyridinoline in assessment of response to local radiation therapy for metastatic bone disease.

机译：尿钙和脱氧吡啶啉对转移性骨病局部放疗的反应评估。

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摘要

To evaluate the predictability of urine calcium (Ca+2) and deoxypyridinoline (DPD) in the assessment of response to palliative radiation therapy (RT) for metastatic bone disease. Forty-two patients with osteolytic bone metastases from breast or lung primaries were enrolled in this study. Serial urine Ca+2 and DPD measurements were performed before RT, six weeks, and twelve weeks afterwards. All eligible patients received a total of 30 Gy RT in 3 Gy daily fractions. Pre-irradiation mean urine Ca+2 and DPD levels were 16 +/- 3.7 g/micromol/dL, and 89.2 +/- 61 pmol/micromol crea. Both were significantly higher than normal range. A significant correlation between pre-irradiation Ca+2 (r = 0.6, p < 0.001), DPD (r = 0.8, p < 0.001) levels and the extent of bone metastases were detected. Thirty-six patients (Group I) were alive without disease progression outside the radiation portal. Urine Ca+2 and DPD levels demonstrated a significant and progressive decrease following RT in Group I patients (p < 0.001). Clinical and radiological evaluation revealed occurrence of new bone metastases in six patients (Group II), with concurrent significant increase in concentrations of urine DPD and Ca+2 (p = 0.006 for Ca+2 and p = 0.009 for DPD, respectively). Urine Ca+2 and DPD levels can be used for assessment of response of bone to local irradiation, and are able to predict further progression of bone metastases in cancer patients.
机译：在评估对姑息性放射治疗（RT）对转移性骨病的反应中，评估尿钙（Ca + 2）和脱氧吡啶啉（DPD）的可预测性。本研究纳入了42例来自乳腺或肺原发性骨溶解性骨转移的患者。在RT之前，六周和此后十二周进行连续尿Ca + 2和DPD测量。所有符合条件的患者均按每日3 Gy的分数接受总的30 Gy RT。辐照前平均尿Ca + 2和DPD水平为16 +/- 3.7 g / micromol / dL和89.2 +/- 61 pmol / micromol crea。两者均显着高于正常范围。检测到辐射前Ca + 2（r = 0.6，p <0.001），DPD（r = 0.8，p <0.001）水平与骨转移程度之间存在显着相关性。三十六名患者（第一组）在放射门外还没有疾病进展。 I组患者在放疗后尿液中的Ca + 2和DPD水平显示出明显且逐步的下降（p <0.001）。临床和放射学评估显示，六名患者（第二组）发生了新的骨转移，同时尿DPD和Ca + 2的浓度显着增加（Ca + 2分别为p = 0.006和DPD分别为p = 0.009）。尿钙+ 2和DPD水平可用于评估骨对局部照射的反应，并能够预测癌症患者骨转移的进一步进展。

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