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首页> 外文期刊>Journal of experimental & clinical cancer research : >Time course of urinary neopterin in a non-Hodgkin's lymphoma patient during chemotherapy and radiotherapy.
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Time course of urinary neopterin in a non-Hodgkin's lymphoma patient during chemotherapy and radiotherapy.

机译：非霍奇金淋巴瘤患者化疗和放疗期间尿新蝶呤的时程。

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摘要

The objective of this study was to follow urinary neopterin in a patient affected by non-Hodgkin's lymphoma during the three months treatment from the onset of the disease. In the study a patient affected by non-Hodgkin's lymphoma in Stage IV (centrocyto-centroblastic type) was enrolled. He was treated with combined chemotherapy and local radiotherapy. Neopterin was measured by high performance liquid chromatography in the first morning urine specimens. The time course of urinary neopterin levels ranged from 110 to 524 micromol x mol(-1) creatinine (mean 261, SD 67.5 micromol x mol(-1) creatinine). Over 70 % of the received values were higher than the upper limit of normal excretion of healthy subjects. Longitudinal analysis showed a relatively big variance of urinary neopterin with a tendency of decrease during the treatment. The significant decrease of urinary neopterin was observed till after the radiotherapy period which followed the chemotherapy period. In conclusions, the response to the therapy was accompanied by a reversal tendency of neopterin excretion to physiological values. This study confirms neopterin as a suitable additional parameter for the control of non-Hodgkin's lymphoma therapy.
机译：这项研究的目的是在疾病发作后的三个月内，对患有非霍奇金淋巴瘤的患者进行尿新蝶呤治疗。在这项研究中，招募了一名患有非霍奇金淋巴瘤的IV期患者（中心细胞-中心粒细胞型）。他接受了化学疗法和局部放疗的联合治疗。通过高效液相色谱法在第一个早晨尿液样本中测量新蝶呤。尿新蝶呤水平随时间变化的范围为110至524 micromol x mol（-1）肌酐（平均261，SD 67.5 micromol x mol（-1）肌酐）。超过70％的接收值高于健康受试者正常排泄的上限。纵向分析显示，尿新蝶呤变化较大，在治疗过程中呈下降趋势。观察到直到化疗之后的放疗期后，尿新蝶呤的显着减少。总之，对该疗法的反应伴随着新蝶呤排泄到生理值的逆转趋势。这项研究证实新蝶呤是控制非霍奇金淋巴瘤治疗的合适附加参数。

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