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首页> 外文期刊>Journal of experimental & clinical cancer research : >High risk of gallbladder carcinoma in elderly patients with segmental adenomyomatosis of the gallbladder.
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High risk of gallbladder carcinoma in elderly patients with segmental adenomyomatosis of the gallbladder.

机译：胆囊段性腺肌瘤病的老年患者胆囊癌的高风险。

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The clinical significance of adenomyomatosis of the gallbladder remains unclear. This study aimed to clarify the relationship between segmental adenomyomatosis and gallbladder carcinoma, and to elucidate the histogenesis of gallbladder carcinoma associated with segmental adenomyomatosis. A total of 4,560 consecutive patients underwent cholecystectomy. The specimens were examined grossly and histologically. Adenomyomatosis of the gallbladder was divided into segmental, fundal, and diffuse types. Sixty noncancerous gallbladders with segmental adenomyomatosis were examined for epithelial metaplasia. The incidence of gallbladder carcinoma was higher in patients with segmental adenomyomatosis (22/334, 6.6%) than in those without (181/4226, 4.3%; P=0.049). This difference was more marked among patients equal to or older than 60 years of age (15/96,15.6% versus 147/2407, 6.1%, respectively; P<0.001). The other types of adenomyomatosis did not show any significant increases in the incidence of gallbladder carcinoma. In all 22 patients with both segmental adenomyomatosis and carcinoma, the tumors developed only in the fundal mucosa. Epithelial metaplasia was more marked in the fundal mucosa of segmental adenomyomatosis than in the neck mucosa (P=0.003). Segmental adenomyomatosis is a high-risk condition for gallbladder carcinoma, especially in elderly patients. Epithelial metaplasia appears to be related to increased carcinogenesis in the fundal mucosa of segmental adenomyomatosis.
机译：胆囊腺肌瘤的临床意义尚不清楚。本研究旨在阐明节段性子宫腺肌瘤病与胆囊癌之间的关系，并阐明与节段性子宫腺肌瘤病相关的胆囊癌的组织发生。总共4,560名连续患者接受了胆囊切除术。对标本进行了肉眼和组织学检查。胆囊腺腺瘤病分为节段型，眼底型和弥漫型。检查了60例部分腺肌瘤病的非癌性胆囊的上皮化生。节段性子宫腺肌病患者的胆囊癌发生率较高（22 / 334，6.6％），而无部分子宫腺肌瘤的患者（181 / 4226，4.3％; P = 0.049）。在等于或大于60岁的患者中，这种差异更为明显（分别为15 / 96,15.6％和147/2407，6.1％; P <0.001）。其他类型的子宫腺肌病未显示胆囊癌的发生率有明显增加。在所有22例既有节段性子宫腺瘤病又有癌的患者中，肿瘤仅在眼底粘膜中发展。节段性子宫腺瘤病的底部粘膜比颈部粘膜的上皮化生更明显（P = 0.003）。节段性子宫腺肌病是胆囊癌的高危疾病，尤其是在老年患者中。上皮化生似乎与节段性子宫腺瘤病的基底粘膜中致癌作用增加有关。

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