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首页> 外文期刊>Journal of Experimental Botany >Genetic analysis of metabolites in apple fruits indicates an mQTL hotspot for phenolic compounds on linkage group 16.
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Genetic analysis of metabolites in apple fruits indicates an mQTL hotspot for phenolic compounds on linkage group 16.

机译：苹果果实中代谢产物的遗传分析表明，第16个连接基团上的酚类化合物存在mQTL热点。

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摘要

Apple (Malus x domestica Borkh) is among the main sources of phenolic compounds in the human diet. The genetic basis of the quantitative variations of these potentially beneficial phenolic compounds was investigated. A segregating F1 population was used to map metabolite quantitative trait loci (mQTLs). Untargeted metabolic profiling of peel and flesh tissues of ripe fruits was performed using liquid chromatography-mass spectrometry (LC-MS), resulting in the detection of 418 metabolites in peel and 254 in flesh. In mQTL mapping using MetaNetwork, 669 significant mQTLs were detected: 488 in the peel and 181 in the flesh. Four linkage groups (LGs), LG1, LG8, LG13, and LG16, were found to contain mQTL hotspots, mainly regulating metabolites that belong to the phenylpropanoid pathway. The genetics of annotated metabolites was studied in more detail using MapQTLReg.. A number of quercetin conjugates had mQTLs on LG1 or LG13. The most important mQTL hotspot with the largest number of metabolites was detected on LG16: mQTLs for 33 peel-related and 17 flesh-related phenolic compounds. Structural genes involved in the phenylpropanoid biosynthetic pathway were located, using the apple genome sequence. The structural gene leucoanthocyanidin reductase (LAR1) was in the mQTL hotspot on LG16, as were seven transcription factor genes. The authors believe that this is the first time that a QTL analysis was performed on such a high number of metabolites in an outbreeding plant species
机译：苹果是人类饮食中酚类化合物的主要来源之一。研究了这些潜在有益的酚类化合物的定量变化的遗传基础。使用隔离的F 1 群体绘制代谢物定量性状位点（mQTL）。使用液相色谱-质谱（LC-MS）对成熟果实的果皮和果肉组织进行非目标代谢谱分析，结果检测到果皮中418种代谢物和果肉中254种代谢产物。在使用MetaNetwork的mQTL定位中，检测到669个重要的mQTL：果皮中488个，肉中181个。发现四个连接基团（LG），LG1，LG8，LG13和LG16包含mQTL热点，主要调节属于苯丙烷途径的代谢产物。使用MapQTL Reg。 对带注释的代谢物的遗传学进行了更详细的研究。许多槲皮素共轭物在LG1或LG13上具有mQTL。在LG16上检测到了代谢物数量最多的最重要的mQTL热点：33个与果皮相关和17个与肉相关的酚类化合物的mQTL。利用苹果基因组序列，找到了参与苯丙烷生物合成途径的结构基因。结构基因花青素还原酶（ LAR1 ）位于LG16的mQTL热点，同样是七个转录因子基因。作者认为这是首次对近交植物物种中如此大量的代谢物进行QTL分析

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