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首页> 外文期刊>Journal of Experimental Botany >Distinct patterns of the histone marks associated with recruitment of the methionine chain-elongation pathway from leucine biosynthesis
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Distinct patterns of the histone marks associated with recruitment of the methionine chain-elongation pathway from leucine biosynthesis

机译：组蛋白标记的不同模式与亮氨酸生物合成中蛋氨酸链延伸途径的募集有关

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摘要

Aliphatic glucosinolates (GLSs) are derived from chain-elongated methionine produced by an iterative three-step process, known to be evolutionarily recruited from leucine biosynthesis. The divergence of homologous genes between two pathways is mainly linked to the alterations in biochemical features. In this study, it was discovered that a distinct pattern of histone modifications is associated with and/or contributes to the divergence of the two pathways. In general, genes involved in leucine biosynthesis were robustly associated with H3k4me2 and H3K4me3. In contrast, despite the considerable abundances of H3K4me2 observed in some of genes involved in methionine chain elongation, H3K4me3 was completely missing. This H3K4m3-depleted pattern had no effect on gene transcription, whereas it seemingly co-evolved with the entire pathway of aliphatic GLS biosynthesis. The results reveal a novel association of the epigenetic marks with plant secondary metabolism, and may help to understand the recruitment of the methionine chain-elongation pathway from leucine biosynthesis.
机译：脂肪族芥子油苷（GLS）衍生自通过三步迭代过程产生的链延长的蛋氨酸，已知该过程是从亮氨酸生物合成中进化而来。两种途径之间同源基因的差异主要与生化特征的改变有关。在该研究中，发现组蛋白修饰的独特模式与两种途径的发散有关和/或促成这两种途径的发散。通常，参与亮氨酸生物合成的基因与H3k4me2和H3K4me3紧密相关。相反，尽管在一些蛋氨酸链延长相关基因中观察到大量H3K4me2，但H3K4me3完全缺失。这种H3K4m3耗尽的模式对基因转录没有影响，而它似乎与脂肪族GLS生物合成的整个途径共同进化。结果揭示了表观遗传标记与植物次级代谢的新型关联，并可能有助于了解亮氨酸生物合成中蛋氨酸链延长途径的募集。

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