Beware of the biologicals-hospitals may die: The rheumatism foundation hospital, heinola, finland (1951-2010)

KauppiM.J.; S?il?H.; BeltE.A.; HakalaM.

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Beware of the biologicals-hospitals may die: The rheumatism foundation hospital, heinola, finland (1951-2010)

机译：当心生物医院可能会死亡：风湿病基金会医院，芬兰海诺拉（1951-2010）

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The first patient entered the Rheumatism Foundation Hospital, Heinola, Finland in July 1951. From that point on, the hospital helped patients suffering from rheumatic disorders. Specialists in the hospital actively developed treatments and published a large number of scientific articles in international journals. The hospital was well known internationally among people working in the field. Progress in the development of disease-modifying medication (biological agents in particular) has dramatically improved the life of patients with rheumatic diseases, but all effective treatments may also have adverse effects. In this article, we briefly review the history of the Rheumatism Foundation Hospital, which was closed permanently in March 2010 due to bankruptcy. The economical difficulties were caused primarily by the progress made in diseasemodifying therapy, which decreased the need of rehabilitation and operative treatment of patients with rheumatic diseases. It seems that a great success in biological agents can carry "serious adverse effects", which may kill hospitals. This is an important primary observation, which should be noticed when the future of specialised institutes is planned.

机译：第一位患者于1951年7月进入芬兰海诺拉的风湿病基金会医院。从那以后，该医院为患有风湿病的患者提供了帮助。医院的专家们积极开发治疗方法，并在国际期刊上发表了大量科学文章。该医院在该领域的工作人员中享誉国际。疾病改良药物（尤其是生物制剂）的开发进展显着改善了风湿病患者的生活，但所有有效的治疗方法也可能产生不良影响。在本文中，我们简要回顾了风湿病基金会医院的历史，该医院因破产于2010年3月永久关闭。经济上的困难主要是由疾病改良疗法的进步所引起的，这减少了对风湿性疾病患者的康复和手术治疗的需求。看来，生物制剂的巨大成功会带来“严重的副作用”，这可能会杀死医院。这是一个重要的主要观察结果，在规划专门机构的未来时应注意。

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《Clinical rheumatology》 |2012年第8期|共4页
作者
KauppiM.J.; S?il?H.; BeltE.A.; HakalaM.;
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正文语种 eng
中图分类内科学;
关键词
Adverse effect; Arthritis; Biological agents; Medical history;

机译：不良反应;关节炎;生物制剂;病史;

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1. Beware of the biologicals-hospitals may die: The rheumatism foundation hospital, heinola, finland (1951-2010) [J] . KauppiM.J., S?il?H., BeltE.A., Clinical rheumatology . 2012,第8期

机译：当心生物医院可能会死亡：风湿病基金会医院，芬兰海诺拉（1951-2010）
2. Work-related empowerment of the multidisciplinary team at the Rheumatism Foundation Hospital. [J] . Suominen T, Savikko N, Kukkurainen M, International journal of nursing practice . 2006,第2期

机译：风湿病基金会医院多学科团队的工作相关授权。
3. TEXTBOOK OF THE RHEUMATIC DISEASES. Edited by W. S. C. Copeman, O.B.E., M.D., F.R.C.P., Senior Physician, Arthur Stanley Institute for Rheumatic Diseases, Middlesex Hospital, Physician in charge of Department of Rheumatic Diseases, West London Hospital, Chairman, Empire Rheumatism Council, and late President, European League against Rheumatism; with twenty-five other contributors. Second edition. 9? x 7? in. Pp. viii+754, with 349 figures, 11 in colour. Index. 1955. Edinburgh and London: E. & S. Livingstone Ltd. Price 52s. 6d [J] . Norman Capener The Journal of Bone and Joint Surgery. British VolumecBritish Orthopaedic Association , Australian Orthopaedic Association , Canadian Orthopaedic Association . . . [et al] . 1955,第2期

机译：风湿病的教科书。由WSC Copeman，OBE，MD，FRCP，亚瑟·史丹利风湿病研究所高级医师，米德尔塞克斯医院，西伦敦医院风湿病科医师，帝国风湿病委员会主席，欧洲联盟反对联盟已故主席编辑风湿病;与其他25个贡献者。第二版。 9？ x 7？ in。Pp。 viii + 754，具有349个数字，11个颜色。指数。 1955年。爱丁堡和伦敦：E。＆S. Livingstone Ltd.价格52s。 6天
4. HOSPITAL FOUNDATIONS: COMPENSATION AND RESULTS BY U.S. REGION AND ASSOCIATED HOSPITAL SIZE [C] . Mary E. Malliaris, Maria Pappas, Thomas W. Whitaker Jr. Annual meeting of the Decision Sciences Institute . 2009

机译：医院基础：美国地区和相关医院规模的补偿和结果
5. Importance of selected competencies/responsibilities for hospital food and nutrition services department directors as perceived by current dietetic program directors, hospital food and nutrition services directors, and hospital administrators. [D] . Shelton, Lyndsey M. 2004

机译：当前的饮食计划主管，医院食品和营养服务主管以及医院管理人员认为，选定的能力/职责对医院食品和营养服务部门主管的重要性。
6. Hospital Facts and Observations Illustrative of the Efficacy of the New Remedies Strychnia Brucia Acetate of Morphia Veratria Iodine c. in Several Morbid Conditions of the System; with a Comparative View of the Treatment of Chorea and Some Cases of Diabetes a Report on the Efficacy of Sulphureous Fumigations in Diseases of the Skin Chronic Rheumatism c. [O] . 1830

机译：医院事实和观察说明新疗法的功效马兜铃属布鲁西亚吗啡乙酸酯藜芦碘等。在系统的几种病态条件下；以治疗舞蹈症和一些糖尿病的比较研究为例关于皮肤慢性风湿病等中亚硫酸盐熏蒸的疗效报告。
7. Vasoactive Intestinal Peptide (VIP)/Pituitary Adenylate Cyclase-Activating Peptide Receptor Subtypes in Mouse Calvarial Osteoblasts: Presence of VIP-2 Receptors and Differentiation-Induced Expression of VIP-1 Receptors**The present study was supported by grants from the Swedish Medical Research Council (7525), the Swedish Rheumatism Association, the Royal 80 Year Fund of King Gustav V, the A-G Crafoord Foundation, the County Council of Västerbotten, the Swedish Dental Society, the Swedish Society for Medical Research, The Wellcome Trust, Monsanto Inc., the Finnish Academy of Science, and an EMBO Fellowship to Petri Lehenkari. [O] . Pernilla Lundberg, Inger Lundgren, Hitoshi Mukohyama, 2001

机译：血管活性肠肽（VIP）/垂体腺苷酸环酶激活肽受体亚型在小鼠颅骨成骨细胞中：VIP-2受体的存在和VIP-1受体的分化诱导的表达**本研究来自瑞典医学研究的补助金议员（7525年），瑞典风湿病协会，皇家古斯塔夫·基金会皇家80年基金，瑞典医学研究瑞典医学协会，瑞典医学协会，蒙斯托公司瑞典医学委员会。，芬兰科学院，以及佩特里莱恩卡里的Embo奖学金。
8. Hospital Facilities as Work Environments: Evaluation Studies in the Operating,Radiology, and Emergency Departments in Seven Finnish General Hospitals [R] . Teikari, M. 1995

机译：医院设施作为工作环境：七家芬兰综合医院的手术，放射科和急诊科的评估研究

Beware of the biologicals-hospitals may die: The rheumatism foundation hospital, heinola, finland (1951-2010)

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