• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Equine Veterinary Science >Pharmacokinetics of IV Ketorolac in Horses Undergoing Orchiectomy
【24h】

Pharmacokinetics of IV Ketorolac in Horses Undergoing Orchiectomy

机译：接受睾丸切除术的马匹中IV酮咯酸的药代动力学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ketorolac (KET) is a nonsteroidal anti-inflammatory drug for human use, with a potent analgesic activity, that is used in the relief of moderate-to-severe postoperative pain. The pharmacokinetics of KET tromethamine was evaluated after single IV injection at 0.5 mg/kg body weight, after intubation and 10 minutes before surgery, to six Arabian colts undergoing orchiectomy. Intraoperative cardiorespiratory variables were monitored. Blood samples were collected for 36 hours, and serum samples were analyzed by high performance liquid chromotography with ultraviolet-visible detection. During surgery, all monitored physiological parameters were stable. Intermittent positive pressure ventilation, and normocapnia were maintained throughout the procedure in all animals. No adverse effects were observed. The kinetics of KET was described by a two-compartment models, and also a noncompartmental analysis was performed. The distribution and elimination half-lives were t(1/2 lambda 1) 0.06 +/- 0.02 and t(1/2 lambda 2) 0.59 +/- 0.21 hours, respectively. Body clearance and mean residence time were 339.99 +/- 120.19 mL/h/kg and 0.49 +/- 0.22 hours, respectively. The volume of distribution at steady state and volume of distribution based on the terminal phase were 218.83 +/- 134.26 mL/kg and 522.5 +/- 529.3 mL/kg, respectively. The serum protein binding was 75.8 +/- 2.9%. The results indicate that KET at 0.5 mg/kg IV was very rapidly eliminated and thus was likely not effective in the postoperative period. However, further studies including a control group and at higher doses are suggested to investigate the KET kinetics and the analgesic efficacy in horse and define the most appropriate dosage scheme
机译：酮咯酸（KET）是一种用于人类的非甾体类抗炎药，具有有效的镇痛作用，可用于缓解中度至重度的术后疼痛。在插管后和手术前10分钟，对六只接受睾丸切除术的阿拉伯小马进行静脉输注，0.5 mg / kg体重的单次IV注射后，评估KET氨丁三醇的药代动力学。术中监测心肺变量。收集血液样品36小时，并通过具有紫外可见检测的高效液相色谱法分析血清样品。手术期间，所有监测的生理参数均稳定。在整个过程中，所有动物均维持间歇性正压通气和正常碳酸血症。没有观察到不良反应。用两室模型描述了KET的动力学，并且还进行了非室分析。分布和消除半衰期分别为t（1/2 lambda 1）0.06 +/- 0.02和t（1/2 lambda 2）0.59 +/- 0.21小时。身体清除率和平均停留时间分别为339.99 +/- 120.19 mL / h / kg和0.49 +/- 0.22小时。稳态下的分布量和基于末端相的分布量分别为218.83 +/- 134.26 mL / kg和522.5 +/- 529.3 mL / kg。血清蛋白结合率为75.8 +/- 2.9％。结果表明0.5 mg / kg IV的KET很快被消除，因此在术后很可能无效。但是，建议进一步研究，包括对照组和高剂量组，以研究马的KET动力学和镇痛效果，并确定最合适的剂量方案

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号