...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical transplantation. >Supporting medication adherence in renal transplantation (SMART): a pilot RCT to improve adherence to immunosuppressive regimens.
【24h】

Supporting medication adherence in renal transplantation (SMART): a pilot RCT to improve adherence to immunosuppressive regimens.

机译：在肾移植（SMART）中支持药物依从性：一项试验性RCT，可提高对免疫抑制方案的依从性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Although non-adherence to an immunosuppressive regimen (NAH) is a major risk factor for poor outcome after renal transplantation (RTx), very few studies have examined non-adherence intervention in this context. This pilot randomized controlled trial (RCT) tested the efficacy of an educational-behavioural intervention to increase adherence in non-adherent RTx patients. We also assessed how NAH evolves over time. METHODS: Eighteen RTx non-adherent patients (age: 45.6 +/- 1.2 yr; 78.6% male) were randomly assigned to either an intervention group (IG) (n = 6) or an enhanced usual care group (EUCG) (n = 12), the latter receiving the usual clinical care. The IG received one home visit and three telephone interviews. We assessed NAH through electronic monitoring (EM) of medication intake during a nine-month period (three months intervention, six months follow-up). RESULTS: Five of 18 patients withdrew. Inclusion in the study resulted in a remarkable decrease in NAH in both groups over the first three months (IG chi(2) = 3.97, df = 1, p = 0.04; EUCG chi(2) = 3.40, df = 1, p = 0.06). The IG showed the greatest decrease in NAH after three months, although this did not reach statistical significance (at 90 d, chi(2) = 1.05, df = 1, p = 0.31). Thereafter, NAH increased gradually in both groups, reaching comparable levels at the end of the six-month follow-up (i.e. at nine months). CONCLUSION: Our findings suggest an inclusion effect. Although the intervention in this pilot RCT appeared to add further benefit in medication compliance, a lack of statistical power prevented us from making a strong statistical statement.
机译：背景：尽管不遵守免疫抑制方案（NAH）是肾移植（RTx）后不良结局的主要危险因素，但很少有研究在这种情况下检查不遵守干预措施。这项试验性随机对照试验（RCT）测试了教育行为干预在增加非依从性RTx患者依从性方面的功效。我们还评估了NAH如何随着时间演变。方法：将18例RTx非依从性患者（年龄：45.6 +/- 1.2岁;男性78.6％）随机分为干预组（IG）（n = 6）或加强常规护理组（EUCG）（n = 12），后者接受通常的临床护理。 IG进行了一次家访和三次电话采访。我们通过电子监测（EM）评估了九个月期间的药物摄入量（三个月干预，六个月随访）中的NAH。结果：18例患者中有5例退出。纳入研究导致头三个月的两组NAH均显着降低（IG chi（2）= 3.97，df = 1，p = 0.04; EUCG chi（2）= 3.40，df = 1，p = 0.06）。 IG在三个月后显示出NAH的最大降低，尽管这没有达到统计学显着性（在90 d时，chi（2）= 1.05，df = 1，p = 0.31）。此后，两组的NAH逐渐增加，在六个月的随访结束时（即九个月）达到可比较的水平。结论：我们的发现提示有包容作用。尽管在该试验性RCT中的干预措施似乎在药物依从性方面进一步增加了益处，但缺乏统计能力使我们无法做出有力的统计声明。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号