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首页> 外文期刊>Journal of feline medicine and surgery >Congenital diseases of feline muscle and neuromuscular junction.
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Congenital diseases of feline muscle and neuromuscular junction.

机译：先天性猫肌肉和神经肌肉交界处疾病。

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Although muscle diseases occur relatively rarely in cats, a number of congenital feline myopathies have been described over the last 20 years and are reviewed in this paper. Some of them have been reported exclusively in specific breeds, including the hypokalaemic myopathy of Burmese cats, type IV glycogen storage disease in Norwegian Forest cats, or the myopathy of Devon Rex. Other congenital disorders of muscle and neuromuscular junction such as myotonia congenital, dystrophin-deficient hypertrophic feline muscular dystrophy, laminin alpha 2 deficiency, or congenital myasthenia gravis may occur in any cat. A systematic approach is essential in order to efficiently obtain a timely diagnosis in cats showing signs of muscle disease. After a thorough clinical examination, this approach includes blood analyses (eg, serum concentration of muscle enzymes), electrophysiology where available (electromyography, nerve conduction studies), and sampling of muscle biopsies for histological, histochemical and immunohistochemical evaluation. When available, detection of healthy carriers of these genetic disorders is important to eliminate the gene mutations from breeding families. Clinicians regularly receiving feline patients must have a good knowledge of congenital feline myopathies and the features which enable a diagnosis to be made and prognosis given. Besides preserving or restoring the well-being of the myopathic patient, rapid and efficient information and counselling of the breeders are of central importance in order to prevent the recurrence of the problem in specific breeding lines.
机译：尽管猫中的肌肉疾病相对很少见，但在过去的20年中已经描述了许多先天性猫科肌病，本文对此进行了综述。其中一些仅在特定品种中被报道，包括缅甸猫的低血钾性肌病，挪威森林猫的IV型糖原贮积病或德文郡雷克斯的肌病。其他任何先天性肌肉和神经肌肉接头疾病，例如先天性肌强直，肌营养不良蛋白缺乏的肥大性猫肌营养不良，层粘连蛋白α2缺乏或先天性重症肌无力。为了有效地对出现肌肉疾病迹象的猫进行及时诊断，系统的方法至关重要。经过全面的临床检查后，该方法包括血液分析（例如，肌肉酶的血清浓度），可用的电生理学（肌电图，神经传导研究）以及用于组织学，组织化学和免疫组织化学评估的肌肉活检样本。如果可行，检测这些遗传疾病的健康携带者对于消除繁殖家族的基因突变很重要。定期接受猫科动物患者的临床医生必须具有先天性猫科肌病的知识，并且能够做出诊断并给出预后的特征。除了保持或恢复肌病患者的健康外，快速有效的信息和育种者咨询对于防止特定育种系问题的再次发生也至关重要。

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