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首页> 外文期刊>Journal of feline medicine and surgery >Clinical, pathological and immunohistochemical study of feline mammary fibroepithelial hyperplasia following a single injection of depot medroxyprogesterone acetate
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Clinical, pathological and immunohistochemical study of feline mammary fibroepithelial hyperplasia following a single injection of depot medroxyprogesterone acetate

机译：单次注射醋酸甲羟孕酮后猫乳腺纤维上皮增生的临床，病理和免疫组化研究

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摘要

Feline mammary fibroepithelial hyperplasia (FMFH) following a single injection of depot medroxyprogesterone acetate (MPA) was observed in eight intact young queens. The repository compound is marketed as a veterinary product by a local pharmaceutical company with an indication for contraception in cats. The drug was administered according to the recommended doses and injection frequencies. Serum hormone assays performed immediately before neutering and 3 weeks after neutering detected persistently high levels of progesterone suggesting that depot MPA was still exerting its influence. No corpora lutea were found in those cases ruling out ovaries as the main site of progesterone. Immunohistochemistry performed on the hyperplastic mammary glands detected progesterone receptors in the nuclei of ductal cells, and growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the cytoplasm of ductal epithelium. Overdosing should be considered here as the animals received at least 10 mg/kg of depot MPA in a single injection. Progestin-induced local synthesis of GH and IGF-I in mammary epithelial cells is suggested as one of the pathogenic mechanisms involved in the development of FMFH.
机译：在八个完整的年轻女王中，单次注射醋酸甲羟孕酮（MPA）后，猫乳腺纤维上皮增生（FMFH）被观察到。该储存化合物是由当地制药公司以兽药形式销售的，可用于猫的避孕。根据推荐的剂量和注射频率给药。绝育前和绝育后3周进行血清激素检测，发现孕酮水平持续升高，这表明MPA库仍在发挥作用。在那些病例中未发现黄体排除卵巢为孕酮的主要部位。在增生性乳腺上进行的免疫组织化学检测到导管细胞核中的孕激素受体，以及导管上皮细胞质中的生长激素（GH）和胰岛素样生长因子-I（IGF-1）。这里应考虑过量使用，因为动物一次注射至少接受了10 mg / kg的MPA储库。孕激素诱导的GH和IGF-1在乳腺上皮细胞中的局部合成被认为是参与FMFH发展的致病机制之一。

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