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首页> 外文期刊>Journal of feline medicine and surgery >Determination of optimal sampling times for a two blood sample clearance method using 51Cr-EDTA in cats.
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Determination of optimal sampling times for a two blood sample clearance method using 51Cr-EDTA in cats.

机译：使用 51 Cr-EDTA在猫中确定两种血液样本清除方法的最佳采样时间。

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Estimation of the glomerular filtration rate (GFR) is a useful tool in the evaluation of kidney function in feline medicine. GFR can be determined by measuring the rate of tracer disappearance from the blood, and although these measurements are generally performed by multi-sampling techniques, simplified methods are more convenient in clinical practice. The optimal times for a simplified sampling strategy with two blood samples (2BS) for GFR measurement in cats using plasma 51chromium ethylene diamine tetra-acetic acid (51Cr-EDTA) clearance were investigated. After intravenous administration of 51Cr-EDTA, seven blood samples were obtained in 46 cats (19 euthyroid and 27 hyperthyroid cats, none with previously diagnosed chronic kidney disease (CKD)). The plasma clearance was then calculated from the seven point blood kinetics (7BS) and used for comparison to define the optimal sampling strategy by correlating different pairs of time points to the reference method. Mean GFR estimation for the reference method was 3.7+or-2.5 ml/min/kg (mean+or-standard deviation (SD)). Several pairs of sampling times were highly correlated with this reference method (r2 >=0.980), with the best results when the first sample was taken 30 min after tracer injection and the second sample between 198 and 222 min after injection; or with the first sample at 36 min and the second at 234 or 240 min (r2 for both combinations=0.984). Because of the similarity of GFR values obtained with the 2BS method in comparison to the values obtained with the 7BS reference method, the simplified method may offer an alternative for GFR estimation. Although a wide range of GFR values was found in the included group of cats, the applicability should be confirmed in cats suspected of renal disease and with confirmed CKD. Furthermore, although no indications of age-related effect were found in this study, a possible influence of age should be included in future studies.
机译：肾小球滤过率（GFR）的估计是评估猫科动物肾脏功能的有用工具。 GFR可以通过测量血液中示踪剂消失的速率来确定，尽管这些测量通常通过多次采样技术进行，但简化的方法在临床实践中更为方便。使用血浆 51 铬乙二胺四乙酸（ 51 Cr-EDTA）对猫进行GFR测定的两种血液样本（2BS）简化采样策略的最佳时间清除率进行了调查。静脉内施用 51 Cr-EDTA后，在46只猫中获得了7份血样（19例甲状腺功能正常的猫和27例甲状腺功能亢进的猫，均未诊断出慢性肾脏病（CKD））。然后根据七点血液动力学（7BS）计算血浆清除率，并将其用于比较，以通过将不同时间点对与参考方法相关联来定义最佳采样策略。参考方法的平均GFR估算值为3.7+或-2.5 ml / min / kg（平均值或标准偏差（SD））。几对采样时间与此参考方法高度相关（ r 2 2 = 0.984）。由于用2BS方法获得的GFR值与用7BS参考方法获得的值相似，因此简化方法可以为GFR估计提供替代方法。尽管在所包括的猫组中发现了广泛的GFR值，但应在怀疑患有肾脏疾病且已确诊CKD的猫中确认其适用性。此外，尽管在这项研究中没有发现与年龄有关的影响的迹象，但在未来的研究中应包括年龄的可能影响。

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