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首页> 外文期刊>Journal of experimental zoology, Part A. Comparative experimental biology >Role of steroidogenic factor 1 and aromatase in temperature-dependent sex determination in the red-eared slider turtle.
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Role of steroidogenic factor 1 and aromatase in temperature-dependent sex determination in the red-eared slider turtle.

机译：类固醇生成因子1和芳香化酶在红耳slider龟中温度依赖性性别确定中的作用。

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摘要

Red-eared slider turtles are genetically bipotential for sex determination. In this species, as in many other reptiles, incubation temperature of the egg determines gonadal sex. At higher incubation temperatures females are produced and increasing temperature appears to increase estrogen production in the embryonic brain. Treatment of eggs incubating at a male-producing temperature with exogenous estrogen causes ovaries to form. At a female-biased incubation temperature, prevention of estrogen biosynthesis or administration of nonaromatizable androgens results in the development of testes. In mammals, steroidogenic factor 1 (SF-1) regulates most genes required for estrogen biosynthesis, including aromatase. In both mammals and red-eared sliders, SF-1 is differentially expressed in males and females during gonadogenesis. We have examined both SF-1 gene expression and aromatase activity in embryos incubating at different temperatures and after manipulation to change the course of gonadal development. Our findings indicate a central role for SF-1 in enacting the effect of estrogen. Estrogen treatment directly or indirectly downregulates SF-1 and, ultimately, causes development of females. The inhibition of estrogen results in upregulation of SF-1 and male hatchlings. Thus, SF-1 may lie at the center of one molecular crossroad in male versus female differentiation of the red-eared slider. Copyright 2001 Wiley-Liss, Inc.
机译：红耳滑龟在遗传上具有性别决定性。与其他许多爬行动物一样，在这个物种中，卵的孵化温度决定了性腺的性别。在较高的孵育温度下，产生雌性，并且温度升高似乎会增加胚胎脑中的雌激素产生。处理在雄性产卵温度下与外源雌激素一起孵化的卵会导致卵巢形成。在女性偏爱的温育温度下，阻止雌激素的生物合成或不可芳香化的雄激素的使用会导致睾丸的发育。在哺乳动物中，类固醇生成因子1（SF-1）调节雌激素生物合成所需的大多数基因，包括芳香酶。在哺乳动物和红耳滑子中，在性腺生成过程中，SF-1在雄性和雌性中差异表达。我们已经检查了在不同温度下孵育并经操纵改变性腺发育过程的胚胎中的SF-1基因表达和芳香酶活性。我们的发现表明SF-1在发挥雌激素作用中起着核心作用。雌激素治疗直接或间接下调SF-1，并最终导致女性发育。雌激素的抑制导致SF-1和雄性幼鱼的上调。因此，SF-1可能位于红耳滑块的男性和女性分化的一个分子十字路口的中心。版权所有2001 Wiley-Liss，Inc.

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