A new tetrasubstituted alpha-fluoro cyclohexanone bearing a fluoroisopropyl group at C5

Arlette Solladie-Cavallo; Khalid Azyat; Loic Jierry

首页> 外文期刊>Journal of Fluorine Chemistry >A new tetrasubstituted alpha-fluoro cyclohexanone bearing a fluoroisopropyl group at C5

【24h】

A new tetrasubstituted alpha-fluoro cyclohexanone bearing a fluoroisopropyl group at C5

机译：一种新的四取代的α-氟环己酮，在C5处带有氟异丙基

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A new tetrasubstituted cyclohexanone 5 fluorinated at C2 and having a fluoroisopropyl group at C5 has been synthesized in five steps from 3-methyl cyclohexenone and the structure of both diastereomers fully assigned.It is shown that diastereomer Ia having the fluorine atom at C2 in the axial position (in the most populated conformer of this diastereomer) is major and is a good catalyst for epoxidation of trans-olefins by oxone while diastereomer IIe is not.Moreover,only 0.3 equiv.of 5-Ia are necessary and the ketone is totaly recovered after reaction (no Baeyer-Villiger).

机译：从3-甲基环己烯酮分五个步骤合成了在C2处氟化并在C5处具有氟异丙基的新的四取代环己酮5，表明两种非对映异构体Ia的轴向均在C2处具有氟原子。位置（在该非对映异构体的最稠密构象异构体中）是主要的，并且是氧杂环丁烷反式烯烃环氧化的良好催化剂，而非对映异构体IIe则是必要的。此外，仅0.3当量的5-Ia是必需的，并且可以完全回收酮反应后（无Baeyer-Villiger）。

著录项

来源
《Journal of Fluorine Chemistry》 |2006年第11期|共5页
作者
Arlette Solladie-Cavallo; Khalid Azyat; Loic Jierry;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Fluorocyclohexanone; NMR; Organic catalyst; Epoxidation catalyst;

机译：氟环己酮;NMR;有机催化剂;环氧化催化剂;

相似文献

外文文献
中文文献
专利

1. A new tetrasubstituted alpha-fluoro cyclohexanone bearing a fluoroisopropyl group at C5 [J] . Arlette Solladie-Cavallo, Khalid Azyat, Loic Jierry Journal of Fluorine Chemistry . 2006,第11期

机译：一种新的四取代的α-氟环己酮，在C5处带有氟异丙基
2. VCD configuration of enantiopure/-enriched tetrasubstituted -fluoro cyclohexanones and their use for epoxidation of trans-olefins [J] . T. B. Freedman, X. Cao, L. A. Nafie, Chirality: The pharmacological, biological, and chemical consequences of molecular asymmetry . 2004,第7期

机译：对映纯/富集的四取代-氟环己酮的VCD构型及其在反式烯烃的环氧化中的应用
3. Asymmetric Epoxidation of trans-Olefins via Chiral Dioxiranes: A Possible Contribution of axial Approaches in the case of Tri- and Tetrasubstituted #alpha#-Fluoro Cyclohexanones [J] . Arlette Solladie-Cavallo, Laetitia Bouerat, Loic Jierry European journal of organic chemistry . 2001,第23期

机译：通过手性二恶英酮对反式烯烃的不对称环氧化：在三和四取代的＃alpha＃-氟环己酮的轴向方法的可能贡献
4. N,N'-TETRASUBSTITUTED MALONAMIDE DERIVATIVES AND HYDROCHLORIC ACID SOLUTIONS: AN INTERFACIAL STUDY [C] . M. Soledade Santos, Marc F. Cornelia, Joao N. Reis, EPD congress;TMS annual meeting exhibition . 2012

机译：N，N'-四取代的丙二酰胺衍生物和盐酸溶液：界面研究
5. Design and use of recombinant whole cell systems in organic chemistry: Synthetic applications of cyclohexanone monooxygenase, cytochromes P450 and epoxide hydrolases. [D] . Martinez, Carlos Alberto. 2000

机译：重组全细胞系统在有机化学中的设计和使用：环己酮单加氧酶，细胞色素P450和环氧化物水解酶的合成应用。
6. Zn-Catalyzed Multicomponent KA2 Coupling:One-Pot Assembly of Propargylamines Bearing Tetrasubstituted CarbonCenters [O] . NikolaosV. Tzouras, Stavros P. Neofotistos, Georgios C. Vougioukalakis, 2019

机译：锌催化的多组分KA2偶联：含四取代碳的炔丙胺的一锅组件中心
7. Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols [O] . Shengtong Niu, Hao Zhang, Weici Xu, 2021

机译：通过辅助邻相邻醇的动力学分辨率，进入酶联化合物轴承挑战四氢封闭物
8. Calculation of C5 Stresses and Deflections in C5 Due to Thermal and Pressure Loading [R] . Guarino, V. 2008

机译：由热和压力加载计算C5中C5应力和挠度

A new tetrasubstituted alpha-fluoro cyclohexanone bearing a fluoroisopropyl group at C5

摘要

著录项

相似文献

相关主题

期刊订阅