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首页> 外文期刊>Journal of chemotherapy >Neoadjuvant and adjuvant chemotherapy with high-dose ifosfamide, doxorubicin, cisplatin and high-dose methotrexate in non-metastatic osteosarcoma of the extremities: A phase II trial in Japan
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Neoadjuvant and adjuvant chemotherapy with high-dose ifosfamide, doxorubicin, cisplatin and high-dose methotrexate in non-metastatic osteosarcoma of the extremities: A phase II trial in Japan

机译：大剂量异环磷酰胺，阿霉素，顺铂和大剂量甲氨蝶呤在四肢非转移性骨肉瘤中的新辅助和辅助化疗：日本的一项II期试验

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摘要

From 1997 to 2003, 40 patients (all 40 years of age) with non-metastatic osteosarcoma of the extremities were treated with OOS-D and definitive surgery. Two cycles of doxorubicin 90 mg/m2 plus cisplatin 120 mg/m2 and ifosfamide 15 g/m2 were given as neoadjuvant chemotherapy, and two cycles of doxorubicin/cisplatin and ifosfamide, and two cycles of high-dose methotrexate (10-12 g/m2) were given post-operatively. All patients underwent limb salvage surgeries, and 66% showed good response to neoadjuvant chemotherapy. With a median follow-up period of 117 months, 31 of the evaluable 40 patients were continuously disease-free, 7 were currently alive with no evidence of disease, and 2 died of disease. There was no local recurrence. The 5-year event-free and overall survival rates were 83 and 98%, respectively. The 10-year event-free and overall survival rates were 80 and 95%, respectively. The major form of toxicity was haematological one. ? 2013 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia.
机译：从1997年到2003年，对40例四肢均非转移性骨肉瘤患者（均<40岁）进行了OOS-D和根治性手术治疗。给予两个周期的阿霉素90 mg / m2加顺铂120 mg / m2和异环磷酰胺15 g / m2作为新辅助化疗，并给予两个周期的阿霉素/顺铂和异环磷酰胺，以及两个周期的高剂量甲氨蝶呤（10-12 g / m2）。手术后给予。所有患者均接受了肢体抢救手术，其中66％的患者对新辅助化疗反应良好。中位随访期为117个月，可评估的40例患者中有31例持续无病，目前7例尚无疾病迹象，尚有2例死亡。没有局部复发。 5年无事件生存率和总生存率分别为83％和98％。 10年无事件生存率和总生存率分别为80％和95％。毒性的主要形式是血液学。 ？ 2013年农业信息与科学学报。

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