5-Substituted pyrimidine 1,5-anhydrohexitols: conformational analysis and interaction with viral thymidine kinase.

Wouters J; Herdewijn P

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >5-Substituted pyrimidine 1,5-anhydrohexitols: conformational analysis and interaction with viral thymidine kinase.

【24h】

5-Substituted pyrimidine 1,5-anhydrohexitols: conformational analysis and interaction with viral thymidine kinase.

机译：5位取代的嘧啶1,5-脱水己糖醇：构象分析及与病毒胸苷激酶的相互作用。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Conformational analysis of anhydrohexitol nucleosides using a combination of experimental (X-ray crystallography) and computational methods indicates that those antiviral compounds occur in an equilibrium between two forms, one conformation being adopted in solid phase and in solution, the other found when the nucleosides are in complex with HSV-1 thymidine kinase. The conformational change induced by the enzyme has been investigated.

机译：结合实验（X射线晶体学）和计算方法对脱水己糖醇核苷进行构象分析，结果表明，这些抗病毒化合物以两种形式之间的平衡存在，一种形式为固相和溶液形式，另一种形式为核苷存在时。与HSV-1胸苷激酶复合。已经研究了由酶诱导的构象变化。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |1999年第11期|共4页
作者
Wouters J; Herdewijn P;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
Pyrimidines; Thymidine Kinase; 嘧啶类; 胸苷激酶;

机译：Pyrimidines;Thymidine Kinase;嘧啶类;胸苷激酶;

相似文献

外文文献
中文文献
专利

1. 5-Substituted pyrimidine 1,5-anhydrohexitols: conformational analysis and interaction with viral thymidine kinase. [J] . Wouters J, Herdewijn P Bioorganic and Medicinal Chemistry Letters . 1999,第11期

机译：5位取代的嘧啶1,5-脱水己糖醇：构象分析及与病毒胸苷激酶的相互作用。
2. A comparison between immobilized pyrimidine nucleoside phosphorylase from Bacillus subtilis and thymidine phosphorylase from Escherichia coli in the synthesis of 5-substituted pyrimidine 2/-deoxyribonucleosides [J] . Immacolata Serra, Teodora Bavaro, Davide A. Cecchini Journal of molecular catalysis, B. Enzymatic . 2013,第Null期

机译：枯草芽孢杆菌固定化嘧啶核苷磷酸化酶与大肠杆菌胸苷磷酸化酶在5-取代的嘧啶2 /-脱氧核糖核苷合成中的比较
3. Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. [J] . Sienaert Rebecca, Naesens Lieve, Brancale Andrea, Molecular pharmacology. . 2002,第2期

机译：VZV编码的胸苷激酶可特异性识别双环嘧啶核苷类似物，这是一类新型的高效有效的水痘带状疱疹病毒（VZV）抑制剂。
4. Conformational Analysis of the HIV-1 Viral Infectivity Factor (Vif) Protein using Hydrogen Exchange Mass Spectrometry [C] . Sean R. Marcsisin, Marek Kloczewiak, Andrew J. Brazier, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：使用氢气交换质谱法的HIV-1病毒感染因子（VIF）蛋白的构象分析
5. Controlling self-assembled monolayer morphology with dipolar interactions: Preparation, STM image analysis and simulations of 1,5-(disubstituted)-anthracene monolayers. [D] . Tong, Wenjun. 2010

机译：通过偶极相互作用控制自组装单分子层的形态：1,5-（双取代）-蒽单分子层的制备，STM图像分析和模拟。
6. Proton NMR study and conformational analysis of d(CGT) d(TCG) and d(CGTCG) in aqueous solution. The effect of a dangling thymidine and of a thymidine mismatch on DNA mini-duplexes. [O] . J R Mellema, R van der Woerd, G A van der Marel, 1984

机译：水溶液中d（CGT）d（TCG）和d（CGTCG）的质子NMR研究和构象分析。悬垂的胸苷和胸苷错配对DNA微型双链体的影响。
7. Synthesis of 5-Substituted 3-Amino-1H-Pyrazole-4-Carbonitriles as Precursors for Microwave Assisted Regiospecific Syntheses of Pyrazolo[1,5-a]Pyrimidines [O] . Fawzia Al-Qalaf, Faisal Mandani, Abeer Abdulrahman Bassam, 2008

机译：5-取代的3-氨基-1H-吡唑-4-碳腈的合成为微波辅助吡唑并[1,5-a]嘧啶的区域特异性合成
8. Structure/Function Analysis of DNA-glycosylases That Repair Oxidized Purines and Pyrimidines and the Influence of Surrounding DNA Sequence on Their Interactions [R] . 2005

机译：修复氧化嘌呤和嘧啶的DNa-糖基化酶的结构/功能分析及其周围DNa序列对其相互作用的影响

5-Substituted pyrimidine 1,5-anhydrohexitols: conformational analysis and interaction with viral thymidine kinase.

摘要

著录项

相似文献

相关主题

期刊订阅