Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate.

Jacobs SA; Vidnovic N; Patel H; Soma LA; Chang Y; Bass N; Swerdlow SH

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Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate.

机译：甲氨蝶呤治疗的类风湿性关节炎患者持久消除了艾滋病毒阴性的卡波西氏肉瘤疱疹病毒相关的卡波西氏肉瘤。

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Multicentric Castleman disease (MCD) is a nonneoplastic lymphoproliferative disorder that has a poor prognosis. Optimal treatment is unknown. There are a few reported cases of MCD and rheumatoid arthritis. In this study, we report a patient with rheumatoid arthritis diagnosed with Kaposi's sarcoma herpesvirus-(KSHV, human herpesvirus-8) associated MCD that showed expression of viral IL-6. Treatment with methotrexate (MTX) resulted in a complete remission of her disease lasting for 54+ months. Multiple studies have suggested that MCD and rheumatoid arthritis are associated with overexpression of the growth-promoting cytokine interleukin-6 (IL-6), and that MTX downregulates the production of this cytokine in vivo. As such, we suggest that the dramatic improvement in this patient's disease is due to the immunomodulatory properties of MTX.

机译：多中心Castleman病（MCD）是一种非肿瘤性淋巴增生性疾病，预后较差。最佳治疗尚不清楚。有一些报道的MCD和类风湿关节炎病例。在这项研究中，我们报告了一名风湿性关节炎患者，其诊断为卡波西氏肉瘤疱疹病毒（KSHV，人类疱疹病毒8）相关的MCD，表达病毒IL-6。甲氨蝶呤（MTX）治疗可使她的疾病完全缓解，持续54个月以上。多项研究表明，MCD和类风湿性关节炎与促进生长的细胞因子白介素6（IL-6）的过表达有关，MTX在体内下调了这种细胞因子的产生。因此，我们认为该患者疾病的显着改善归因于MTX的免疫调节特性。

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来源
《Clinical rheumatology》 |2007年第7期|共3页
作者
Jacobs SA; Vidnovic N; Patel H; Soma LA; Chang Y; Bass N; Swerdlow SH;
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正文语种 eng
中图分类自身免疫性疾病、结缔组织疾病;
关键词
Methotrexate; Rheumatoid Arthritis; Patients; Kaposi Sarcoma; Interleukin-6;

机译：甲氨蝶呤;类风湿关节炎;患者;卡波济肉瘤;白介素6;

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1. Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate. [J] . Jacobs SA, Vidnovic N, Patel H, Clinical rheumatology . 2007,第7期

机译：甲氨蝶呤治疗的类风湿性关节炎患者持久消除了艾滋病毒阴性的卡波西氏肉瘤疱疹病毒相关的卡波西氏肉瘤。
2. Kaposi Sarcoma Herpes Virus-associated Hemophagocytic Syndrome Complicated by Multicentric Castleman Disease and Kaposi Sarcoma in a HIV-negative Immunocompetent Patient: An Autopsy Case [J] . Kim Bomi, Jeon Yoon Kyung, Kim Chul Woo Journal of Korean medical science. . 2009,第5期

机译：卡波西肉瘤疱疹病毒相关的吞噬细胞综合征并发多中心Castleman病和卡波西肉瘤在HIV阴性免疫功能正常的患者：尸检病例。
3. Development of Kaposi's sarcoma after complete remission of multicentric Castlemans disease with rituximab therapy in a HHV8-positive, HIV-negative patient. [J] . Law AB, Ryan G, Lade S, International journal of hematology . 2010,第2期

机译：在HHV8阳性，HIV阴性的患者中，利妥昔单抗治疗完全缓解了多中心性Castlemans病后，卡波济肉瘤的发展。
4. Early disease control by low-dose prednisone comedication may affect the quality of remission In patients with early rheumatoid arthritis [C] . Monica Todoerti, Carlo Alberto Scire, Nicola Boffini, International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases . 2010

机译：低剂量泼尼松的早期疾病控制可能会影响早期类风湿性关节炎患者的缓解质量
5. Best Practice for Screening Adult Patients with Psoriasis for Polyautoimmunity: Celiac Disease, Rheumatoid Arthritis and Crohn's Disease [D] . Ashbaugh, Susan Danielle. 2017

机译：筛查成年多发性银屑病患者的最佳实践：乳糜泻，类风湿关节炎和克罗恩氏病
6. Kaposi Sarcoma Herpes Virus-associated Hemophagocytic Syndrome Complicated by Multicentric Castleman Disease and Kaposi Sarcoma in a HIV-negative Immunocompetent Patient: An Autopsy Case [O] . Bomi Kim, Yoon Kyung Jeon, Chul Woo Kim 2009

机译：卡波西肉瘤疱疹病毒相关的噬血细胞综合征并发多中心Castleman病和卡波西肉瘤在HIV阴性免疫功能正常的患者：尸检病例。
7. Kaposi Sarcoma Herpes Virus-associated Hemophagocytic Syndrome Complicated by Multicentric Castleman Disease and Kaposi Sarcoma in a HIV-negative Immunocompetent Patient: An Autopsy Case [O] . Kim, Bomi, Jeon, Yoon Kyung, Kim, Chul Woo 2009

机译：卡波西肉瘤疱疹病毒相关的吞噬细胞综合征并发多中心Castleman病和卡波西肉瘤在HIV阴性免疫功能正常的患者：尸检病例。

Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate.

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