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首页> 外文期刊>Journal of genetics >Beneficial role of D allele in controlling ACE levels: a study among Brahmins of north India
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Beneficial role of D allele in controlling ACE levels: a study among Brahmins of north India

机译：D等位基因在控制ACE水平中的有益作用：印度北部婆罗门的一项研究

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India being a country with vast diversity is expected to have different dietary and life style patterns which in turn may lead to population-specific environmental risk factors. Further, the interaction of these risk factors with the genetic makeup of population makes it either susceptible or resistant to cardiovascular disease. One such candidate gene is angiotensin converting enzyme (ACE) for various cardiovascular mechanisms. ACE is the key enzyme of the renin angiotensin aldosterone system pathway which maintains homeostasis blood pressure in the body and any variation in the levels is reported to be associated with various complex diseases. The DD genotype is found to increase ACE levels, which is associated with cardiovascular diseases and decrease in ACE levels are associated with kidney diseases. The aim of this study was to understand the distribution of ACE I/D polymorphism and ACE levels among Brahmins of National Capital Region (NCR) north India, with respect to age and sex ratio distribution. In this study, 136 subjects of which 50 males and 86 females, who were unrelated up to first cousin, aged 25 to70 years were studied. ACE gene was found to be polymorphic with high frequency of heterozygote (ID) followed by II and DD genotypes. The studied population was found to be in Hardy-Weinberg equilibrium with respect to ACE I/D polymorphism (P = 0.55). I allele frequency was found to be higher (0.560) than the D allele (0.44). The median level of ACE was found to be 65.96 ng/mL (48.12-86.24) which is towards lower side of the normal range. ACE levels were found to be increased among individual having either of the homozygotes that is II or DD and higher frequency of heterozygote (ID) is indicative of advantage in the population by maintaining lower ACE levels. The limitation of the present study is low sample size, however, the merit is that the subjects belonged to a Mendalian population with a common gene pool.
机译：印度是一个拥有广泛多样性的国家，有望拥有不同的饮食和生活方式，这又可能导致特定人群的环境风险因素。此外，这些危险因素与人群遗传组成的相互作用使它易患或抵抗心血管疾病。一种这样的候选基因是用于各种心血管机制的血管紧张素转化酶（ACE）。 ACE是肾素血管紧张素醛固酮系统通路的关键酶，可维持体内血压的动态平衡，据报道其水平的任何变化均与多种复杂疾病有关。发现DD基因型增加ACE水平，这与心血管疾病有关，而ACE水平降低与肾脏疾病有关。这项研究的目的是了解印度北部国家首都区（NCR）婆罗门中ACE I / D多态性和ACE水平的分布，以及年龄和性别比分布。在这项研究中，研究对象是136名受试者，其中50名男性和86名女性与第一堂兄弟姐妹无关，年龄在25至70岁之间。发现ACE基因是多态的，杂合子（ID）的频率高，其次是II和DD基因型。就ACE I / D多态性而言，研究人群处于Hardy-Weinberg平衡状态（P = 0.55）。发现I等位基因频率比D等位基因（0.44）更高（0.560）。发现ACE的中位数水平为65.96 ng / mL（48.12-86.24），接近正常范围的下限。发现具有II或DD纯合子的个体中ACE水平升高，并且杂合子（ID）的较高频率表明通过维持较低ACE水平在人群中具有优势。本研究的局限性在于样本量低，但是，其优点是受试者属于具有共同基因库的Mendalian种群。

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