• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of genetics >Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene × gender interaction
【24h】

Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene × gender interaction

机译：HS6ST3基因多态性与肥胖和甘油三酸酯的关联：基因×性别相互作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) gene is involved in heparan sulphate and heparin metabolism, and has been reported to be associated with diabetic retinopathy in type 2 diabetes.We hypothesized that HS6ST3 gene polymorphisms might play an important role in obesity and related phenotypes (such as triglycerides). We examined genetic associations of single-nucleotide polymorphisms (SNPs) within the HS6ST3 gene with obesity and triglycerides using two Caucasian samples: the Marshfield sample (1442 obesity cases and 2122 controls), and the Health aging and body composition (Health ABC) sample (305 cases and 1336 controls). Logistic regression analysis of obesity as a binary trait and linear regression analysis of triglycerides as a continuous trait, adjusted for age and sex, were performed using PLINK. Single marker analysis showed that six SNPs in the Marshfield sample and one SNP in the Health ABC sample were associated with obesity (P <0.05). SNP rs535812 revealed a stronger association with obesity in meta-analysis of these two samples (P = 0.0105). The A haplotype from rs878950 and rs9525149 revealed significant association with obesity in the Marshfield sample (P = 0.012). Moreover, nine SNPs showed associations with triglycerides in the Marshfield sample (P < 0.05) and the best signal was rs1927796 (P = 0.00858). In addition, rs7331762 showed a strong gene × gender interaction (P = 0.00956) for obesity while rs1927796 showed a strong gene × gender interaction (P = 0.000625) for triglycerides in the Marshfield sample. These findings contribute new insights into the pathogenesis of obesity and triglycerides and demonstrate the importance of gender differences in the aetiology.
机译：硫酸乙酰肝素6-O-磺基转移酶3（HS6ST3）基因参与硫酸乙酰肝素和肝素代谢，据报道与2型糖尿病糖尿病视网膜病变有关。我们假设HS6ST3基因多态性可能在肥胖中起重要作用和相关的表型（例如甘油三酸酯）。我们使用两个白种人样本检验了HS6ST3基因内的单核苷酸多态性（SNP）与肥胖症和甘油三酸酯的遗传关联：Marshfield样本（1442个肥胖症病例和2122个对照）以及Health衰老和身体成分（Health ABC）样本（ 305个案例和1336个控件）。使用PLINK对肥胖进行二元性的Logistic回归分析，并对甘油三酸酯作为连续性进行线性回归分析（根据年龄和性别进行调整）。单标记分析显示，Marshfield样本中的6个SNP和Health ABC样本中的1个SNP与肥胖相关（P <0.05）。 SNP rs535812在这两个样品的荟萃分析中显示出与肥胖的关联更强（P = 0.0105）。 rs878950和rs9525149的A单倍型显示与Marshfield样本中的肥胖有显着相关性（P = 0.012）。此外，在Marshfield样品中有9个SNPs与甘油三酸酯相关（P <0.05），最佳信号是rs1927796（P = 0.00858）。此外，在Marshfield样本中，肥胖的rs7331762显示了很强的基因×性别相互作用（P = 0.00956），而肥胖的rs1927796显示了很强的基因×性别相互作用（P = 0.000625）。这些发现为肥胖和甘油三酸酯的发病机理提供了新的见识，并证明了性别差异在病因学中的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号