Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences.

Reddy PM; Bruice TC

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences.

【24h】

Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences.

机译：带正电荷的脱氧核苷胍（DNG）寡核苷酸混合序列的固相合成。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Positively charged DNG oligonucleotide mixed sequences containing A/T bases were prepared by solid-phase synthesis. Synthesis proceeds in 3'-->5' direction and involves coupling of 3'-Fmoc protected thiourea in the presence of HgCl(2)/TEA with the corresponding 5'-amine of the growing oligo chain. DNG binding characteristics with complementary DNA and with itself have been evaluated.

机译：通过固相合成制备含有A / T碱基的带正电荷的DNG寡核苷酸混合序列。合成过程按3'-> 5'方向进行，涉及在HgCl（2）/ TEA存在下3'-Fmoc保护的硫脲与增长中的寡链的相应5'-胺的偶联。已经评估了DNG与互补DNA及其自身的结合特性。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2003年第7期|共5页
作者
Reddy PM; Bruice TC;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
Solid; Oligonucleotides; deoxynucleic guanidine; Phase; Synthesis; 寡核苷酸类;

机译：Solid;Oligonucleotides;deoxynucleic guanidine;Phase;Synthesis;寡核苷酸类;

相似文献

外文文献
中文文献
专利

1. Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences. [J] . Reddy PM, Bruice TC Bioorganic and Medicinal Chemistry Letters . 2003,第7期

机译：带正电荷的脱氧核苷胍（DNG）寡核苷酸混合序列的固相合成。
2. Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide incorporating 7-deazaguanine bases. [J] . Jain ML, Bruice TC Bioorganic and Medicinal Chemistry . 2006,第21期

机译：包含7-脱氮鸟嘌呤碱基的带正电荷的脱氧核苷胍（DNG）寡核苷酸的固相合成。
3. Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) modified oligonucleotides containing neutral urea linkages: effect of charge deletions on binding and fidelity. [J] . Linkletter BA, Bruice TC Bioorganic and medicinal chemistry . 2000,第8期

机译：含中性脲键的带正电荷的脱氧核苷胍（DNG）修饰寡核苷酸的固相合成：电荷缺失对结合和保真度的影响。
4. Influence of the cationic lipid structure on the oligonucleotide release from submicron positively-charged emulsions [C] . H.Texeira, C.Dubernet, S.Benita, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：阳离子脂质结构对亚微米带正电乳液中寡核苷酸释放的影响
5. Synthesis and Biophysical Characterization of O2'-Intercalator-Functionalized Oligonucleotides for Mixed-Sequence Recognition of Double -Stranded DNA. [D] . Karmakar, Saswata. 2013

机译：用于双链DNA混合序列识别的O2'-嵌入剂官能化寡核苷酸的合成和生物物理表征。
6. Solid-phase synthesis of oligopurine deoxynucleic guanidine (DNG) and analysis of binding with DNA oligomers [O] . Barry A. Linkletter, Istvan E. Szabo, Thomas C. Bruice 2001

机译：固相合成寡嘌呤脱氧核苷胍（DNG）的结合分析 DNA寡聚体
7. Solid-Phase Synthesis of Positively Charged Deoxynucleic Guanidine (DNG) Tethering a Hoechst 33258 Analogue: Triplex and Duplex Stabilization by Simultaneous Minor Groove Binding [O] . -1

机译：带正电荷的脱氧核苷酸（DNG）的固相合成Hoechst 33258类似物：通过同时轻微沟绑定进行三链和双链体稳定

Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences.

摘要

著录项

相似文献

相关主题

期刊订阅