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首页> 外文期刊>Journal of genetics >Association of PPAR gamma gene polymorphisms with osteoarthritis in a southeast Chinese population
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Association of PPAR gamma gene polymorphisms with osteoarthritis in a southeast Chinese population

机译：中国东南部人群中PPARγ基因多态性与骨关节炎的关系

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摘要

Primary osteoarthritis (OA) is a leading cause of disability in developed countries. Currently no satisfactory treatment to stop disease progression exists. Recent studies suggest that activation of the transcription factor peroxisome proliferator-activated receptor gamma (PPAR gamma) is an interesting therapeutic target for this disease. PPAR gamma is a transcription factor important for adipogenesis and adipocyte differentiation. Agonists of PPAR gamma inhibit inflammation and reduce generation of cartilage degradation products both in vitro and in vivo, and reduce the development/progression of cartilage lesions in OA animal models. However, there are no studies to assess the role of PPAR gamma in OA susceptibility of human peripheral joints in a Chinese population. We conducted a case-control study in a southeast Chinese population to determine the association of PPAR gamma gene polymorphisms (rs1801282, rs12629751, rs2292101, rs4135275 and rs1175543) with OA. One-hundred knee OA cases and 100 controls were studied. Statistically significant differences were detected in genotype and allele frequencies between OA and control groups in this population. For knee OA, the highest risk was associated with the variant allele T of the single-nucleotide polymorphism rs12629751 (odds ratio (OR): 0.341, 95% confidence interval (CI):0.173-0.673, P = 0.002), and allele T of SNP rs12629751 (chi-square: 9.546, P = 0.002) could be considered as a risk factor of knee OA. Therefore, PPAR gamma mutation could be associated with the incidence of OA in a Chinese population. There is a significant association between the PPAR gamma polymorphism rs12629751 and susceptibility to knee OA in a southeast Chinese population.
机译：原发性骨关节炎（OA）是发达国家致残的主要原因。目前，尚无令人满意的治疗方法可阻止疾病进展。最近的研究表明，转录因子过氧化物酶体增殖物激活的受体γ（PPARγ）的激活是该疾病的一个有趣的治疗目标。 PPARγ是对脂肪生成和脂肪细胞分化重要的转录因子。在OA动物模型中，PPARγ激动剂可在体外和体内抑制炎症反应并减少软骨降解产物的产生，并减少软骨损伤的发展/进程。但是，尚无研究评估PPARγ在中国人群中人外周关节的OA易感性中的作用。我们在东南中国人群中进行了病例对照研究，以确定PPARγ基因多态性（rs1801282，rs12629751，rs2292101，rs4135275和rs1175543）与OA的关联。研究了一百例膝骨关节炎病例和100例对照。在该人群中，OA和对照组之间在基因型和等位基因频率上检测到统计学上的显着差异。对于膝盖OA，最高风险与单核苷酸多态性rs12629751的变异等位基因T相关（比值比（OR）：0.341，95％置信区间（CI）：0.173-0.673，P = 0.002）和等位基因T SNP rs12629751（卡方：9.546，P = 0.002）可能被认为是膝盖OA的危险因素。因此，PPARγ突变可能与中国人群OA的发生有关。在中国东南部人群中，PPARγ多态性rs12629751与对膝盖OA的易感性之间存在显着关联。

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