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首页> 外文期刊>Journal of genetics >Comparative analysis of ADS gene promoter in seven Artemisia species
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Comparative analysis of ADS gene promoter in seven Artemisia species

机译：七个蒿种ADS基因启动子的比较分析

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摘要

Artemisinin is the most effective antimalarial drug that is derived from Artemisia annua. Amorpha-4,11-diene synthase (ADS) controls the first committed step in artemisinin biosynthesis. The ADS gene expression is regulated by transcription factors which bind to the cis-acting elements on the ADS promoter and are probably responsible for the ADS gene expression difference in the Artemisia species. To identify the elements that are significantly involved in ADS gene expression, the ADS gene promoter of the seven Artemisia species was isolated and comparative analysis was performed on the ADS promoter sequences of these species. Results revealed that some of the cis-elements were unique or in terms of number were more in the high artemisinin producer species, A. annua, than the other species. We have reported that the light-responsive elements, W-box, CAAT-box, 5-UTR py-rich stretch, TATA-box sequence and tandem repeat sequences have been identified as important factors in the increased expression of ADS gene.
机译：青蒿素是衍生自青蒿的最有效的抗疟药。 Amorpha-4,11-二烯合酶（ADS）控制青蒿素生物合成的第一步。 ADS基因的表达受转录因子的调控，该转录因子与ADS启动子上的顺式作用元件结合，可能是蒿种中ADS基因表达差异的原因。为了鉴定与ADS基因表达显着相关的元件，分离了七个蒿属物种的ADS基因启动子，并对这些物种的ADS启动子序列进行了比较分析。结果显示，在青蒿素高产种A. annua中，某些顺式元素是独特的，或在数量上比其他物种更多。我们已经报道了光响应元件，W框，CAAT框，富含5-UTR py的拉伸，TATA框序列和串联重复序列已被确定为ADS基因表达增加的重要因素。

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