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首页> 外文期刊>Journal of genetics >Association of MITF gene with hearing and pigmentation phenotype in Hedlund white American mink (Neovison vison)
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Association of MITF gene with hearing and pigmentation phenotype in Hedlund white American mink (Neovison vison)

机译：MITF基因与Hedlund白色美国水貂（Neovison vison）的听力和色素沉着表型的关联

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摘要

Microphthalmia-associated transcription factor (MITF) is an important regulatory factor involved in the migration of melanocytes during embryonic development. Similar to other described species, in the American mink too, the MITF gene seems to be associated with lack of pigment and deafness, although no significant mutation has been identified in the gene. By histochemical methods, melanin granules were for the first time revealed in the stria vascularis in wt mink but also in the vestibular membrane, a location never reported before. In the cochleas from deaf Hedlund mink (hh), no staining was observed. Keywords. American mink; Hedlund white; albino; deafness; MITF gene.
机译：小眼症相关转录因子（MITF）是在胚胎发育过程中涉及黑素细胞迁移的重要调控因子。与其他描述的物种相似，在美国水貂中，尽管尚未在基因中鉴定出明显的突变，但MITF基因似乎与色素缺乏和耳聋有关。通过组织化学方法，首次在wt貂的血管纹中以及在前庭膜中发现了黑色素颗粒。在聋的Hedlund貂（hh）的耳蜗中，未观察到染色。关键字。美国貂皮; Hedlund白色;白化病耳聋MITF基因。

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