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首页> 外文期刊>Journal of genetics >Y-SNP haplogroups related to the Yqh+ heteromorphism in the Mexican northwestern population
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Y-SNP haplogroups related to the Yqh+ heteromorphism in the Mexican northwestern population

机译：与墨西哥西北人群Yqh +异质性有关的Y-SNP单倍群

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摘要

Morphological variation of the Y chromosome has been observed in different populations. This variation is mostly related to the heteromorphic Yq12 band, which is composed of a variable block of constitutive heterochromatin. The Yqh+ heteromorphism has a worldwide frequency of 2.85% and is considered clinically innocuous. The aim of this study was to identify the ancestry of the Yqh+ heteromorphism present in individuals from western Mexico. For this purpose, 17 Y-chromosome single nucleotide polymorphisms were analysed by multiplex polymerase chain reaction and SNaPshot assays. In 28 Yqh+ males, only five haplogroups were observed; with a haplogroup diversity of 0.4841 ± 0.1094, which was less than that observed in a study of unselected Mexican mestizo population. Differences were specifically conferred by the high frequencies of haplogroups R1b1 and P*(xQ,R), and by the absence of the Amerindian haplogroup Q (Q*(xQ1a3a) plus Q1a3a) from the Yqh+ group. This study suggests a post-1492 incorporation for Yqh+ chromosomes into the Mexican northwestern population.
机译：在不同人群中观察到Y染色体的形态变异。这种变化主要与由组成型异染色质的可变块组成的异型Yq12带有关。 Yqh +异质性在世界范围内的发生率为2.85％，在临床上被认为是无害的。这项研究的目的是确定存在于墨西哥西部个体中的Yqh +异质性的祖先。为此，通过多重聚合酶链反应和SNaPshot分析法分析了17个Y染色体单核苷酸多态性。在28个Yqh +男性中，仅观察到5个单倍群。的单倍群多样性为0.4841±0.1094，这比在未选择的墨西哥混血儿种群研究中观察到的要少。特别是由于单倍群R1b1和P *（xQ，R）的高频率，以及不存在来自Yqh +组的美洲印第安人单倍群Q（Q *（xQ1a3a）和Q1a3a），造成了差异。这项研究表明，在1492年后，Yqh +染色体并入了墨西哥西北部人群。

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