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首页> 外文期刊>Clinical rheumatology >The relationship between alcohol intake and cellular immune activity in systemic lupus erythematosus may change from inhibitory to stimulatory within 2 months of study: findings from an integrative single-case study.
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The relationship between alcohol intake and cellular immune activity in systemic lupus erythematosus may change from inhibitory to stimulatory within 2 months of study: findings from an integrative single-case study.

机译：在研究的2个月内，系统性红斑狼疮的酒精摄入与细胞免疫活性之间的关系可能会从抑制性变为刺激性：一项综合性单例研究的结果。

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摘要

Alcoholic beverages such as beer and wine contain several compounds (e.g. ethanol and antioxidants) that potentially counteract inflammatory diseases such as systemic lupus erythematosus (SLE) [1]. However, evidence on the association between alcohol consumption and SLE disease activity is equivocal. While meta-analyses by Wang et al. revealed that alcohol drinking might be protective in SLE [2], their own most recent empirical work did not support this observation [3]. This inconsistency may arise from the inability of conventional group studies to appropriately handle the subjective and temporal qualities characterizing the association between drinking alcohol and physiological response [4]. In order to better deal with complex psychosomatic features, we have developed an integrative research approach based on extensive single-case studies [5]. Using this approach, it was shown in a 40-year-old patient with SLE that daily alcohol consumption was associated with a decline in levels of urinary neopterin, an immune activation marker and indicator of SLE activity [6], within 24 h after intake [5].
机译：含酒精的饮料，例如啤酒和葡萄酒，含有几种化合物（例如，系统性红斑狼疮（SLE）），可以潜在地抵抗炎症性疾病[1]。但是，关于饮酒与SLE疾病活动之间关系的证据是模棱两可的。虽然王等人的荟萃分析。有研究表明，饮酒可能对SLE有保护作用[2]，他们最近的实证研究并不支持这一观察[3]。这种不一致可能是由于常规的小组研究无法适当处理表征饮酒与生理反应之间联系的主观和时间品质所致[4]。为了更好地处理复杂的心身特征，我们基于广泛的单例研究[5]开发了一种综合研究方法。使用这种方法，在一名40岁的SLE患者中发现，摄入后24小时之内，每日饮酒与尿新蝶呤，一种免疫激活标志物和SLE活性指标[6]的下降有关。 [5]。

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