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首页> 外文期刊>Journal of exposure science & environmental epidemiology >Intra- and inter-individual variability of urinary phthalate metabolite concentrations in Hmong women of reproductive age.
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Intra- and inter-individual variability of urinary phthalate metabolite concentrations in Hmong women of reproductive age.

机译：苗族苗族妇女尿中邻苯二甲酸酯代谢物浓度的个体内和个体间差异。

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The reproducibility of urinary phthalate metabolite concentrations has not been well characterized in non-pregnant women of reproductive age. Our primary study objectives were to describe the distribution of urinary phthalate metabolites concentrations among a population of Hmong women of reproductive age, and to evaluate intra- and inter-individual variability of phthalate metabolite concentrations. Ten phthalate metabolites were measured in first-morning urine samples collected from 45 women and 20 of their spouses, who were members of the Fox River Environment and Diet Study cohort in Green Bay, Wisconsin. Repeated first-morning urine samples were collected and analyzed from 25 women, who provided up to three samples over approximately 1 month. Measurement variability was assessed using intraclass correlations (ICCs) and surrogate category analysis. Linear mixed models were used to evaluate the associations between participant characteristics and phthalate metabolite concentrations. Nine of the 10 phthalate metabolites were detected in >80% of all analyzed samples, of which seven were detected in all samples. As a measure of reliability, ICCs were strongest for monobenzyl phthalate (0.64) and weakest for the metabolites of di(2-ethylhexyl)phthalate (DEHP) (ranging from 0.13 to 0.22). Similarly, surrogate category analysis suggested that a single urine sample characterized an average 1-month exposure with reasonable accuracy across low, medium and high tertiles for all metabolites, except the DEHP metabolites. Geometric mean concentrations of monoethyl phthalate increased with age, but patterns by education, income, body mass index, environmental tobacco smoke or season were not observed when measures were adjusted for urinary dilution. Our results suggest that the participant characteristics assessed in this study have limited influence on inter-individual variability of phthalate metabolite concentrations. With regard to intra-individual variability, our results suggest that urinary concentrations of some phthalate metabolites are more reproducible over time and are less subjected to exposure misclassification than others (e.g., metabolites of DEHP).
机译：在未怀孕的育龄妇女中，尿邻苯二甲酸酯代谢物浓度的可再现性尚未得到很好的表征。我们的主要研究目的是描述在育龄的苗族妇女中尿中邻苯二甲酸酯代谢物浓度的分布，并评估个体间和个体间邻苯二甲酸酯代谢物浓度的变化。在来自威斯康星州格林贝的福克斯河环境与饮食研究小组的45名妇女及其配偶中，从初次采集的尿液样本中测量了10种邻苯二甲酸酯代谢物。从25名妇女中收集并分析了重复的初次尿液样本，这些妇女在大约1个月的时间内提供了多达三个样本。使用组内相关性（ICC）和替代类别分析评估测量变异性。使用线性混合模型评估参与者特征与邻苯二甲酸酯代谢物浓度之间的关联。在所有分析样品中，> 80％的样品中检出了10种邻苯二甲酸酯代谢物中的9种，其中所有样品中检出7种。作为可靠性的度量，邻苯二甲酸单苄基酯（0.64）的ICC最强，邻苯二甲酸二（2-乙基己基）酯（DEHP）的代谢产物的ICC最弱（0.13至0.22）。同样，替代品类别分析表明，单个尿液样本可表征除DEHP代谢物以外的所有代谢物的低，中和高三分位数的平均1个月暴露，具有合理的准确性。邻苯二甲酸单乙酯的几何平均浓度随着年龄的增长而增加，但在调整尿液稀释措施时，未观察到受教育程度，收入，体重指数，环境烟尘或季节的变化。我们的结果表明，在这项研究中评估的参与者特征对邻苯二甲酸酯代谢物浓度的个体间差异具有有限的影响。关于个体内部的变异性，我们的结果表明，随着时间的推移，某些邻苯二甲酸酯代谢物的尿液浓度具有更高的重现性，并且与其他代谢物（例如DEHP的代谢物）相比，其暴露分类错误更少。

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