• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of genetics >Rethinking inheritance, yet again: inheritomes, contextomes and dynamic phenotypes
【24h】

Rethinking inheritance, yet again: inheritomes, contextomes and dynamic phenotypes

机译：重新考虑继承：继承基因组，上下文组和动态表型

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In recent years, there have been many calls for an extended evolutionary synthesis, based in part upon growing evidence for nongenetic mechanisms of inheritance, i.e., similarities in phenotype between parents and offspring that are not due to shared genes. While there has been an impressive marshalling of evidence for diverse forms of nongenetic inheritance (epigenetic, ecological, behavioural and symbolic), there have been relatively few studies trying to integrate the different forms of inheritance into a common conceptual structure, a development that would be important to formalize elements of the extended evolutionary synthesis. Here, we propose a framework for an extended view of inheritance and introduce some conceptual distinctions that we believe, are important to this issue. In this framework, the phenotype is conceived of as a dynamic entity, its state, at any point in time resulting from intertwined effects of previous phenotypic state, and of hereditary materials (DNA and otherwise) and environment. We contrast our framework with the standard gene-based view of inheritance, and also discuss our framework in the specific context of recent attempts to accommodate nongenetic inheritance within the framework of classical quantitative genetics and the Price equation. In particular, we believe that the extended view of inheritance and effects on the phenotype developed here is particularly well-suited to individual-based simulation studies of evolutionary dynamics. The results of such simulations, in turn, could be useful for assessing, how well extended models based on quantitative genetics or the Price equation perform at capturing complex evolutionary dynamics.
机译：近年来，已经有许多要求扩展的进化合成的要求，这部分地基于越来越多的遗传非遗传机制的证据，即，非共有基因的父母和后代在表型上的相似性。尽管有令人印象深刻的证据证明各种形式的非遗传继承（表观遗传，生态，行为和象征），但很少有研究试图将不同形式的遗传整合到一个共同的概念结构中，对于形式化扩展进化综合的要素非常重要。在这里，我们提出了一个扩展的继承框架，并介绍了我们认为对这个问题很重要的一些概念上的区别。在此框架中，表型被认为是动态实体，其状态在任何时间点都是由于先前表型状态与遗传物质（DNA和其他）和环境的相互影响而产生的。我们将我们的框架与基于标准基因的遗传观点进行了对比，并在最近尝试在经典定量遗传学和Price方程框架内适应非遗传遗传的特定背景下讨论了我们的框架。特别是，我们认为，这里继承的继承性及其对表型的影响的扩展视图特别适合于基于个体的进化动力学模拟研究。反过来，这些模拟的结果对于评估基于定量遗传学或Price方程的扩展模型在捕获复杂的进化动力学方面的表现可能非常有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号