首页> 外文期刊>Journal of genetics >Evolutionary history of the somatostatin and somatostatin receptors
【24h】

Evolutionary history of the somatostatin and somatostatin receptors

机译:生长抑素和生长抑素受体的进化史

获取原文
获取原文并翻译 | 示例
           

摘要

Somatostatin and its receptors have a critical role in mammalian growth through their control pattern of secretion of growth hormone, but the evolutionary history of somatostatin and somatostatin receptors are ill defined. We used comparative whole genome analysis of Danio rerio, Carassius auratus, Xenopus tropicalis, Gallus gallus, Monodelphis domestica, Homo sapiens, Sus scrofa, Bos taurus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Ovis aries, Equus caballus, Pan troglodytes and Macaca mulatto to identify somatostatin and somatostatin receptors in each species. To date, we have identified a minimum of two genes of somatostatin and five somatostatin receptor genes in mammalian species with variable forms. We established a clear evolutionary history of the somatostatin system and traced the origin of the somatostatin system to 395 million years ago (MYA), identifying critical steps in their evolution.
机译:生长抑素及其受体通过控制生长激素分泌的方式在哺乳动物的生长中起着至关重要的作用,但是生长抑素和生长抑素受体的进化史尚不清楚。我们使用了比较性的全基因组分析,包括丹尼奥里奥,Car鱼,热带非洲爪蟾,盖氏鸡,家蝇,人,智人,野猪,金牛座,小家鼠,褐家鼠,天狼犬,羊眼,E马,泛袋鼠。猕猴,以识别每种物种中的生长抑素和生长抑素受体。迄今为止,我们已经在具有可变形式的哺乳动物物种中鉴定出至少两个生长抑素基因和五个生长抑素受体基因。我们建立了生长抑素系统的明确进化史,并将生长抑素系统的起源追溯到3.95亿年前(MYA),确定了其发展的关键步骤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号