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首页> 外文期刊>Journal of genetics >Genome association study of human chromosome 13 and susceptibility to coronary artery disease in a Chinese population
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Genome association study of human chromosome 13 and susceptibility to coronary artery disease in a Chinese population

机译：中国人群中人类13号染色体的基因组关联研究及其对冠状动脉疾病的敏感性

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摘要

Coronary artery disease (CAD) is a complex disease and many genetic factors underlie pathogenesis of CAD. Several loci that are associated with susceptibility to CAD have been found. To find the genetic loci associated with CAD in Chinese population we performed a genome scan on chromosome 13 in CAD patients and healthy people from Shandong peninsula. Fourteen microsatellite markers on chromosome 13, spaced at approximately 10 cM, were used to screen DNA pool samples of 156 CAD patients and 1000 normal controls. Statistical analysis was performed using CLUMP software to compare the differences in allele frequency at each locus between the two pooled samples. We found significant statistical differences at D13S263 and D13S156 loci between allele frequencies in patients and those in controls (both, P < 0.05). The data provide support for the existence of two regions on chromosome 13 associated with CAD in this population.
机译：冠状动脉疾病（CAD）是一种复杂的疾病，许多遗传因素是CAD发病机理的基础。已发现与CAD易感性相关的几个基因座。为了找到与中国人群CAD相关的遗传基因座，我们对CAD患者和山东半岛健康人群的13号染色体进行了基因组扫描。 13号染色体上的14个微卫星标记（间隔约10 cM）用于筛选156名CAD患者和1000名正常对照的DNA池样本。使用CLUMP软件进行统计分析，以比较两个合并样本之间每个位点的等位基因频率差异。我们在患者和对照组中的等位基因频率之间在D13S263和D13S156基因座上发现了显着的统计学差异（均P <0.05）。数据为该人群中13号染色体上与CAD相关的两个区域的存在提供了支持。

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