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首页> 外文期刊>Journal of exposure science & environmental epidemiology >Biological monitoring of smoke exposure among wildland firefighters: a pilot study comparing urinary methoxyphenols with personal exposures to carbon monoxide, particular matter, and levoglucosan.
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Biological monitoring of smoke exposure among wildland firefighters: a pilot study comparing urinary methoxyphenols with personal exposures to carbon monoxide, particular matter, and levoglucosan.

机译：在野外消防员中进行烟气暴露的生物监测：一项将尿甲氧基酚与个人暴露于一氧化碳，特殊物质和左旋葡聚糖的暴露进行比较的先导研究。

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Urinary methoxyphenols (MPs) have been proposed as biomarkers of woodsmoke exposure. However, few field studies have been undertaken to evaluate the relationship between woodsmoke exposure and urinary MP concentrations. We conducted a pilot study at the US Forest Service-Savannah River Site, in which carbon monoxide (CO), levoglucosan (LG), and particulate matter (PM(2.5)) exposures were measured in wildland firefighters on prescribed burn days. Pre- and post-shift urine samples were collected from each subject, and cross-shift changes in creatinine-corrected urinary MP concentrations were calculated. Correlations between exposure measures and creatine-adjusted urinary MP concentrations were explored, and regression models were developed relating changes in urinary MP concentrations to measured exposure levels. Full-shift measurements were made on 13 firefighters over 20 work shifts in winter 2004 at the US Forest Service Savannah River site, a National Environmental Research Park. The average workshift length across the 20 measured shifts was 701+/-95 min. LG and CO exposures were significantly correlated for samples where the filter measurement captured at least 60% of the work shift (16 samples), as well as for the smaller set of full-shift exposure samples (n=9). PM(2.5) and CO exposures were not significantly correlated, and LG and PM(2.5) exposures were only significantly correlated for samples representing at least 60% of the work shift. Creatinine-corrected urinary concentrations for 20 of the 22 MPs showed cross-shift increases, with 14 of these changes showing statistical significance. Individual and summed creatinine-adjusted guaiacol urinary MPs were highly associated with CO (and, to a lesser degree, LG) exposure levels, and random-effects regression models including CO and LG exposure levels explained up to 80% of the variance in cross-shift changes in summed creatinine-adjusted guaiacol urinary MP concentrations. Although limited by the small sample size, this pilot study demonstrates that urinary MP concentrations may be effective biomarkers of occupational exposure to wood smoke among wildland firefighters.
机译：尿甲氧基酚（MPs）已被提议作为烟熏暴露的生物标记。但是，很少进行田间研究来评估烟熏暴露与尿中MP浓度之间的关系。我们在美国森林服务局-萨凡纳河站点进行了一项试点研究，在野外消防员中按规定的燃烧天数测量了一氧化碳（CO），左旋葡聚糖（LG）和颗粒物（PM（2.5））的暴露量。从每个受试者收集移位前和移位后尿液样品，并计算肌酐校正的尿MP浓度的交叉移位变化。探索了暴露量度与经肌酸调节的尿MP浓度之间的相关性，并建立了将尿MP浓度变化与测得的暴露水平相关的回归模型。 2004年冬季，在国家森林研究公园美国森林服务局萨凡纳河现场对13名消防员进行了全班制测量，进行了20个工作班次。 20个轮班的平均轮班长度为701 +/- 95分钟。 LG和CO暴露与过滤器测量至少捕获了60％的工作班次的样本（16个样本）以及较小的全班次暴露样本（n = 9）具有显着相关性。 PM（2.5）和CO暴露无显着相关性，而LG和PM（2.5）暴露仅对代表至少60％工作班次的样品显着相关。 22个MP中有20个肌酐校正的尿液浓度显示交叉移位增加，其中14个变化显示统计学意义。单独和总计的肌酐调整后的愈创木酚尿液MP与CO（和LG程度较低）的暴露水平高度相关，包括CO和LG暴露水平在内的随机效应回归模型解释了交叉变异的80％肌酐调整后的愈创木酚尿MP浓度总和的变化。尽管受样本量的限制，但这项先导研究表明，尿MP浓度可能是野外消防员职业性暴露于木烟的有效生物标志物。

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