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首页> 外文期刊>Journal of geriatric oncology >Anaemia in elderly patients with cancer: Focus on chemotherapy-induced anaemia
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Anaemia in elderly patients with cancer: Focus on chemotherapy-induced anaemia

机译：老年癌症患者的贫血：关注化疗引起的贫血

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摘要

Anaemia in general is known to cause fatigue, impaired physical performance, higher risk of falls, prolonged duration of hospitalisation, poor mood, and impaired cognitive function. In patients with cancer, chemotherapy-induced anaemia (CIA) is common, and has also been shown to affect patients' quality of life (QoL). In elderly patients, where up to 60% will develop CIA, the negative impact of these factors on QoL is even more pronounced. This has been recognised by the International Society of Geriatric Oncology (SIOG) and the American Society of Clinical Oncology (ASCO) who both recommend that CIA in elderly patients should be treated. However, due to the biological age and comorbidities of this patient population, careful consideration of potential therapy, concomitant to chemotherapy, is required. Indeed, as we begin to uncover the specific needs of this population of patients with cancer, it is also important to understand whether currently available treatment modalities are still appropriate. In this article, we explore the current evidence in elderly patients for the use of three of the most common therapies for the treatment of CIA: red blood cell transfusions, iron supplementation, and erythropoiesis-stimulating agents.
机译：一般而言，贫血会导致疲劳，身体机能受损，跌倒的风险更高，住院时间延长，情绪低落以及认知功能受损。在患有癌症的患者中，化疗引起的贫血（CIA）很常见，并且也已证明会影响患者的生活质量（QoL）。在老年患者中，高达60％会发展为CIA，这些因素对QoL的负面影响更为明显。这已得到国际老年肿瘤学会（SIOG）和美国临床肿瘤学会（ASCO）的认可，它们均建议应治疗老年患者的CIA。然而，由于该患者群体的生物学年龄和合并症，需要仔细考虑与化学疗法相伴的潜在疗法。确实，随着我们开始发现这一癌症患者群体的特殊需求，了解当前可用的治疗方式是否仍然合适也很重要。在本文中，我们探索了老年患者使用三种最常见的CIA疗法的现有证据：红细胞输血，补铁和促红细胞生成素。

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