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首页> 外文期刊>Journal of geriatric oncology >The impact of fatigue and anemia on functional status in older cancer patients treated with chemotherapy
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The impact of fatigue and anemia on functional status in older cancer patients treated with chemotherapy

机译：疲劳和贫血对化疗后老年癌症患者功能状态的影响

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Objective: Fatigue has multiple causes but the pathogenesis is not completely understood. Fatigue is one of the worst threats to the functional independence of older individuals. The aim of this study is to establish an association between fatigue, anemia and functional dependence in older cancer patients receiving chemotherapy. Materials and methods: Patients aged 70 years or older with a diagnosis of metastatic malignancy were enrolled. All patients were evaluated at the beginning and after 3. months of treatment. A comprehensive geriatric assessment and Fatigue Symptom Inventory (FSI) were used at the beginning and at the end of the study. Results: The final sample involved 129 patients. Almost all fatigue scores had a significant increase from the beginning to the end of treatment. IADLs and PS decreased significantly between the baseline and the final evaluations. The worsening in severity of fatigue, anemia, the increase in interference with daily living as well as the hours of fatigue during the day were associated with disabilities in IADLs. The decline in creatinine value was the only parameter associated with PS. Conclusions: Fatigue is almost universal in older cancer patients at the end of chemotherapy treatment and is associated with functional dependence, especially IADLs. We also established an independent correlation of anemia and functional dependence in older individuals.
机译：目的：疲劳有多种原因，但其发病机理尚不完全清楚。疲劳是老年人功能独立的最严重威胁之一。这项研究的目的是在接受化疗的老年癌症患者中建立疲劳，贫血与功能依赖性之间的联系。材料和方法：纳入诊断为转移性恶性肿瘤的70岁或以上的患者。在治疗开始和治疗三个月后对所有患者进行评估。在研究的开始和结束时使用了综合的老年病评估和疲劳症状清单（FSI）。结果：最终样本包括129名患者。从治疗开始到结束，几乎所有的疲劳评分都有显着提高。在基线和最终评估之间，IADL和PS显着下降。 IADLs的残疾与疲劳严重程度的恶化，贫血，对日常生活的干扰增加以及白天的疲劳时间有关。肌酐值的下降是与PS相关的唯一参数。结论：在化疗结束时，疲劳在老年癌症患者中几乎普遍存在，并且与功能依赖性有关，尤其是IADL。我们还建立了老年患者贫血与功能依赖性的独立相关性。

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