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首页> 外文期刊>Journal of geriatric oncology >Impact of age, comorbidity and symptoms on physical function in long-term breast cancer survivors (CALGB 70803)
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Impact of age, comorbidity and symptoms on physical function in long-term breast cancer survivors (CALGB 70803)

机译：年龄，合并症和症状对长期乳腺癌幸存者身体功能的影响（CALGB 70803）

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Objective: The purpose of this study was to assess the impact of aging, comorbidities and symptoms on physical function in patients surviving 20. years since adjuvant treatment for breast cancer. Patients and methods: Patients were originally treated on CALGB 7581 (from 1975 to 1980), a randomized trial of three adjuvant therapies and reassessed (153 of 193 eligible survivors) 20. years from the onset of therapy for physical function and symptoms by the EORTC QLQ-C30 and comorbidities by the OARS questionnaire. Results: The average age at reassessment was 64.5. years. 66% of patients had at least two comorbidities and 22% had four or more, but relatively little interference with activities. Older patients had greater multimorbidity. Physical function was generally high and comparable to matched population norms. Older patients had greater difficulty with strenuous activities. For every increase in number of comorbidities, physical function score decreased by 5.1 (p < .001). Symptoms were also frequent (80%) and correlated strongly with decreases in function (0-100. u scale) (p < .001), to an even greater degree than comorbidities. Conclusion: Very long-term cancer survivors have changes in physical function and symptoms largely consistent with their aging suggesting that the impact of cancer and its treatment is attenuated over time and largely replaced by the impact of age-related comorbidities and functional decline.
机译：目的：本研究旨在评估年龄，合并症和症状对乳腺癌辅助治疗后幸存的患者20年后身体机能的影响。患者和方法：患者最初接受CALGB 7581治疗（从1975年至1980年），这是一项针对三种辅助疗法的随机试验，并进行了重新评估（193名合格幸存者中的153名），距EORTC开始治疗身体功能和症状20年QLQ-C30和合并症由OARS调查表提供。结果：重新评估的平均年龄为64.5岁。年份。 66％的患者至少患有两种合并症，而22％的患者患有四种以上，但对活动的干扰相对较小。老年患者的多发病率更高。身体机能一般较高，可与人口匹配标准相媲美。老年患者进行剧烈活动的困难更大。合并症每增加一次，身体机能评分就会降低5.1（p <.001）。症状也很常见（80％），并且与功能降低（0-100 u范围）密切相关（p <.001），其程度甚至超过合并症。结论：非常长期的癌症幸存者的身体机能和症状变化与他们的衰老基本一致，这表明随着时间的流逝，癌症及其治疗的影响逐渐减弱，并被年龄相关合并症和功能下降的影响所替代。

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