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首页> 外文期刊>Journal of geriatric psychiatry and neurology >Midlife motivational abilities predict apathy and depression in Alzheimer disease: the aging, demographics, and memory study.
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Midlife motivational abilities predict apathy and depression in Alzheimer disease: the aging, demographics, and memory study.

机译：中年人的动机能力可以预测阿尔茨海默氏病的冷漠和抑郁：衰老，人口统计学和记忆研究。

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摘要

Apathy and depression are the most common neuropsychiatric symptoms in mild cognitive impairment (MCI) and Alzheimer disease (AD). This study was the first to explore midlife motivational abilities as a predictor of the progression of apathy and depression in MCI and AD. It used a subsample of the Aging, Demographics, and Memory Study (N = 137). Participants, aged over 70, were categorized according to baseline clinical diagnosis (normal cognition, MCI, or AD). Assessments were conducted at an 18-month interval. Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory. Midlife motivational abilities were estimated on the basis of the main occupation using the Occupational Information Network (O*NET) database, which provides detailed information on worker abilities. Repeated measures analysis of covariance was used. Apathy and depression were found to be particularly high in participants with AD and high motivational abilities. Apathy, but not depression, increased over time in those with AD and high motivational abilities. It would appear that holding on to unattainable goals with strong motivational efforts when faced with severe cognitive loss might lead to unproductive persistence, depressive reaction, and more apathetic behavior.
机译：冷漠和抑郁是轻度认知障碍（MCI）和阿尔茨海默氏病（AD）中最常见的神经精神症状。这项研究是第一个探索中年动机能力作为MCI和AD的冷漠和抑郁进展预测指标的研究。它使用了“老龄化，人口统计学和记忆研究”的子样本（N = 137）。根据基线临床诊断（正常认知，MCI或AD）对70岁以上的参与者进行分类。评估间隔为18个月。使用神经精神病学清单评估神经精神病症状。使用职业信息网（O * NET）数据库根据主要职业估算中年的动机能力，该数据库提供有关工人能力的详细信息。使用协方差的重复测量分析。发现患有AD和高动机能力的参与者的冷漠和抑郁感特别高。随着时间的流逝，具有AD和高动机能力的人的冷漠而非抑郁感随时间增加。看起来，当面对严重的认知丧失时，通过强有力的动机努力坚持无法实现的目标，可能会导致生产力低下的持续性，沮丧的反应和更多的冷漠行为。

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