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首页> 外文期刊>Journal of geriatric psychiatry and neurology >Development and Validation of the Rappel Indice-24: Behavioral and Brain Morphological Evidence
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Development and Validation of the Rappel Indice-24: Behavioral and Brain Morphological Evidence

机译：Rappel Indice-24的开发和验证：行为和脑形态学证据

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The primary goals of the present study were to develop and validate the Rappel Indice 24 (RI-24), a shorter version of the original Rappel Indice, which includes 48 items (RI-48), and to identify the specific brain regions that were correlated with scores on the RI-24. Using these clinical scales, the present study evaluated 91 elderly Korean participants who were classified into 3 groups: normal control (NC; n = 34), patients with mild cognitive impairment (MCI; n = 29), and patients with Alzheimer disease (AD; n = 28). Of the 91 participants, 77 also underwent magnetic resonance imaging scans. The RI-24 delayed cued recall (DCR) scores significantly differed among the NC, MCI, and AD groups. A receiver-operating characteristic curve analysis revealed that the RI-24 was very sensitive (89%) and specific (91%) for the detection of AD. Furthermore, although the time needed to administer the RI-24 was half that needed for the RI-48, the 24-item version showed a high correlation (r = .85 for the DCR score) with the 48-item version. In terms of brain morphological characteristics, voxel-based morphometry analyses revealed a significant positive correlation between DCR score and gray matter volume in the parahippocampal gyrus (r = .468), which plays a role in cued recall. Taken together, the present findings indicate that the RI-24 is a sensitive and reliable test for the detection of memory impairments in patients with MCI and AD despite its brief administration time.
机译：本研究的主要目标是开发和验证Rappel Indice 24（RI-24），它是原始Rappel Indice的较短版本，其中包括48个项目（RI-48），并确定特定的大脑区域与RI-24上的得分相关。使用这些临床量表，本研究评估了91名韩国老年人，将其分为3组：正常对照（NC; n = 34），轻度认知障碍患者（MCI; n = 29）和阿尔茨海默病（AD） ; n = 28）。在91位参与者中，有77位还进行了磁共振成像扫描。在NC，MCI和AD组之间，RI-24延迟暗示回忆（DCR）得分存在显着差异。接收器操作特性曲线分析显示，RI-24对AD的检测非常敏感（89％）和特异性（91％）。此外，尽管管理RI-24所需的时间是RI-48所需时间的一半，但24项版本显示了与48项版本的高度相关性（DCR评分r = 0.85）。在脑形态学特征方面，基于体素的形态学分析显示，海马旁回中DCR评分与灰质体积之间呈显着正相关（r = .468），这在提示回忆中起作用。综上所述，本发明结果表明，尽管RI-24给药时间短，但它对于检测MCI和AD患者的记忆障碍是一种灵敏可靠的检测方法。

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