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首页> 外文期刊>Biomolecules & therapeutics >Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells
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Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells

机译：自噬调节甲氟喹处理细胞中初级纤毛的形成。

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Primary cilia have critical roles in coordinating multiple cellular signaling pathways. Dysregulation of primary cilia is implicated in various ciliopathies. To identify specific regulators of autophagy, we screened chemical libraries and identified mefloquine, an anti-malaria medicine, as a potent regulator of primary cilia in human retinal pigmented epithelial (RPE) cells. Not only ciliated cells but also primary cilium length was increased in mefloquine-treated RPE cells. Treatment with mefloquine strongly induced the elongation of primary cilia by blocking disassembly of primary cilium. In addition, we found that autophagy was increased in mefloquine-treated cells by enhancing autophagic flux. Both chemical and genetic inhibition of autophagy suppressed ciliogenesis in mefloquine-treated RPE cells. Taken together, these results suggest that autophagy induced by mefloquine positively regulates the elongation of primary cilia in RPE cells.
机译：原发纤毛在协调多种细胞信号通路中起关键作用。原发性纤毛失调与多种纤毛病有关。为了确定自噬的特定调节剂，我们筛选了化学文库并确定了甲氟喹（一种抗疟疾药物）作为人视网膜色素上皮细胞（RPE）中原发纤毛的有效调节剂。在甲氟喹治疗的RPE细胞中，不仅纤毛细胞而且初级纤毛长度都增加了。用甲氟喹治疗通过阻断初级纤毛的分解强烈诱导初级纤毛的伸长。另外，我们发现通过增强自噬通量，甲氟喹处理的细胞自噬增加。自噬的化学和遗传抑制都抑制了甲氟喹处理的RPE细胞的纤毛发生。综上所述，这些结果表明甲氟喹诱导的自噬正调控RPE细胞中初级纤毛的伸长。

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