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首页> 外文期刊>Clinical Pediatrics >A case of invasive Streptococcus pneumoniae in an afebrile adolescent with sickle cell disease
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A case of invasive Streptococcus pneumoniae in an afebrile adolescent with sickle cell disease

机译：高热青少年镰状细胞病侵袭性肺炎链球菌1例

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Introduction: Since the identification of sickle cell disease (SCD) more than 100 years ago, studies have determined that affected patients are at increased risk of certain infections. The natural course of SCD frequently leads to functional asplenia, chronic ischemia, and a dysfunctional immune system, which predisposes patients to infection by encapsulated organisms, specifically Streptococcus pneumoniae? Before the initiation of universal newborn screening for SCD and the subsequent use of penicillin prophylaxis as well as the introduction of vaccination against S pneumoniae, a child with SCD had more than a 300 times greater relative risk of bacterial meningitis than the general population. Since the initiation of penicillin prophylaxis and vaccination with pneumococcal polysaccharide vaccine (PPV-23) and pneumococcal protein-conjugate vaccine (PCV7), the incidence of all Spneumoniae infections in patients with SCD has declined by 68% to 90%. Despite these significant improvements in childhood mortality in persons with SCD, the age of death of an average adult patient with SCD is between 42 and 48 years, approximately 30 years less than the average life expectancy in the United States.8 Furthermore, adults with SCD continue to die as a result of multiorgan failure of unknown etiology as well as acute chest syndrome, in which infectious organisms may be involved.
机译：简介：自从100多年前就鉴定出镰状细胞病（SCD）以来，研究已经确定受影响的患者患某些感染的风险增加。 SCD的自然病程经常导致功能性无力，慢性缺血和免疫系统功能异常，从而使患者更容易感染包封生物，特别是肺炎链球菌？在开始对新生儿SCD进行全面新生儿筛查，随后进行青霉素预防以及针对肺炎链球菌进行疫苗接种之前，患有SCD的儿童患细菌性脑膜炎的相对风险是普通人群的300倍以上。自从开始预防和接种肺炎球菌多糖疫苗（PPV-23）和肺炎球菌蛋白结合疫苗（PCV7）以来，SCD患者所有肺炎感染的发生率已下降68％至90％。尽管SCD患者的儿童死亡率有了显着改善，但SCD成人患者的平均死亡年龄在42至48岁之间，比美国的平均预期寿命低30岁。8此外，SCD成人由于病因不明的多器官衰竭以及可能涉及感染性生物的急性胸综合症而继续死亡。

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