Vaccine Responses and Immunologic Characteristics of Pediatric Patients With DiGeorge Syndrome.

Pui-Ying Iroh Tam; Shane C McAllister

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Vaccine Responses and Immunologic Characteristics of Pediatric Patients With DiGeorge Syndrome.

机译：DiGeorge综合征患儿的疫苗反应和免疫学特征。

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Fumarylacetoacetate hydrolase (FAH) domain-containing proteins occur in both prokaryotes and eukaryotes, where they carry out diverse enzymatic reactions, probably related to structural differences in their respective FAH domains; however, the precise relationship between structure of the FAH domain and the associated enzyme function remains elusive. In mammals, three FAH domain-containing proteins, FAHD1, FAHD2A, and FAHD2B, are known; however, their enzymatic function, if any, remains to be demonstrated. In bacteria, oxaloacetate is subject to enzymatic decarboxylation; however, oxaloacetate decarboxylases (ODx) were so far not identified in eukaryotes. Based on molecular modeling and subsequent biochemical investigations, we identified FAHD1 as a eukaryotic ODx enzyme. The results presented here indicate that dedicated oxaloacetate decarboxylases exist in eukaryotes.

机译：含有富马酸乙酰乙酸酯水解酶（FAH）结构域的蛋白质同时存在于原核生物和真核生物中，它们在其中进行各种酶促反应，可能与各自FAH结构域的结构差异有关。但是，FAH结构域的结构与相关酶功能之间的确切关系仍然难以捉摸。在哺乳动物中，已知三种包含FAH结构域的蛋白质FAHD1，FAHD2A和FAHD2B;但是，它们的酶功能（如果有的话）还有待证明。在细菌中，草酰乙酸酯会发生酶促脱羧作用。然而，到目前为止，在真核生物中尚未发现草酰乙酸脱羧酶（ODx）。基于分子建模和随后的生化研究，我们将FAHD1鉴定为真核ODx酶。此处显示的结果表明真核生物中存在专用的草酰乙酸脱羧酶。

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《Clinical Pediatrics》 |2015年第13期|共3页
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Pui-Ying Iroh Tam; Shane C McAllister;
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1. Vaccine Responses and Immunologic Characteristics of Pediatric Patients With DiGeorge Syndrome. [J] . Pui-Ying Iroh Tam, Shane C McAllister Clinical Pediatrics . 2015,第13期

机译：DiGeorge综合征患儿的疫苗反应和免疫学特征。
2. Safety and efficacy of measles, mumps, and rubella vaccine in patients with DiGeorge syndrome. [J] . Al Sukaiti N, Reid B, Lavi S, The Journal of Allergy and Clinical Immunology . 2010,第4期

机译：DiGeorge综合征患者的麻疹，腮腺炎和风疹疫苗的安全性和有效性。
3. Autoimmunity in a cohort of 130 pediatric patients with partial DiGeorge syndrome. [J] . Tison BE, Nicholas SK, Abramson SL, The Journal of Allergy and Clinical Immunology . 2011,第5期

机译：130名患有部分DiGeorge综合征的儿科患者队列中的自身免疫。
4. Immunologic Mechanism of the Anti-Tumor Immunity Responses Induced by the Altogether Culture Medium of Porcine Cartilage Polysaccharide and S180 Ascites Lump Cells as a Tumor Vaccine [C] . Liu An-jun, Gao Ya, Ma Shan-jie, 5th International Conference on Bioinformatics and Biomedical Engineering . 2011

机译：猪软骨多糖和S180腹水肿块细胞作为肿瘤疫苗共同培养基诱导的抗肿瘤免疫反应的免疫学机制
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机译：I.完全由碳水化合物抗原引起的免疫反应：基于Tn-PS A1共轭物II的癌症疫苗候选物的设计和合成。微波辅助一锅两步合成1,2,4,5-四氢-1,4-苯并二氮杂-3-酮用于癌症治疗。
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Vaccine Responses and Immunologic Characteristics of Pediatric Patients With DiGeorge Syndrome.

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