...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Effect of charged lidocaine on static and dynamic properties of model bio-membranes
【24h】

Effect of charged lidocaine on static and dynamic properties of model bio-membranes

机译：带电利多卡因对模型生物膜静态和动态特性的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effect of the charged lidocaine on the structure and dynamics of DMPC/DMPG (mass fraction of 95/5) unilamellar vesicles has been investigated. Changes in membrane organization caused by the presence of lidocaine were detected through small angle neutron scattering experiments. Our results suggest that the presence of lidocaine in the vicinity of the headgroups of lipid membranes leads to an increase of the area per lipid molecule and to a decrease of membrane thickness. Such changes in membrane structure may induce disordering of the tail group. This scenario explains the reduction of the main transition temperature of lipid membranes, as the fraction of lidocaine per lipid molecules increases, which was evident from differential scanning calorimetry results. Furthermore neutron spin echo spectroscopy was used for the dynamics measurements and the results reveal that presence of charged lidocaine increases the bending elasticity of the lipid membranes in the fluid phase and slows the temperature-dependent change of bending elasticity across the main transition temperature.
机译：研究了带电利多卡因对DMPC / DMPG（质量分数为95/5）单层囊泡的结构和动力学的影响。通过小角中子散射实验检测了由于利多卡因的存在而引起的膜组织变化。我们的结果表明，脂质膜头基附近存在利多卡因会导致每个脂质分子的面积增加并导致膜厚度减小。膜结构的这种变化可能引起尾基混乱。这种情况解释了随着每个脂质分子利多卡因比例的增加，脂质膜的主要转变温度降低，这从差示扫描量热法结果可以明显看出。此外，中子自旋回波光谱法用于动力学测量，结果表明带电利多卡因的存在增加了流体相中脂质膜的弯曲弹性，并减缓了在整个主要转变温度下弯曲弹性的温度依赖性变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号