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首页> 外文期刊>Journal of glaucoma >Macular and retinal nerve fiber layer thickness measurements in normal eyes with the Stratus OCT, the Cirrus HD-OCT, and the Topcon 3D OCT-1000.
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Macular and retinal nerve fiber layer thickness measurements in normal eyes with the Stratus OCT, the Cirrus HD-OCT, and the Topcon 3D OCT-1000.

机译:使用Stratus OCT,Cirrus HD-OCT和Topcon 3D OCT-1000在正常眼睛中测量黄斑和视网膜神经纤维层厚度。

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摘要

PURPOSE: To compare retinal nerve fiber layer (RNFL) and macular thickness measurements using time-domain optical coherence tomography (TD OCT) and 2 Fourier-domain OCTs (FD OCT). METHODS: Sixty eyes of 60 normal participants underwent eye examination followed by OCT evaluation with the time-domain Stratus OCT (Carl Zeiss Meditec, Inc. Dublin, CA) and 2 FD OCTs-the Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA) and the 3D OCT-1000 (Topcon Corporation, Tokyo, Japan). Each patient was scanned 3 times on each machine by the same physician examiner. RNFL and macular thickness measurements were compared across the 3 devices using repeated measures analysis of variance (ANOVA) and multiple comparison t tests with Bonferroni adjustments. The coefficients of variation (CV) and the intraclass correlation coefficients were calculated to assess reproducibility. Bland-Altman plots were constructed to assess the level of agreement between every 2 OCTs. RESULTS: All 3 machines revealed similar patterns of regional differences in RNFL and macular thicknesses. Macular thickness was consistently greatest on the Cirrus and lowest on the Stratus device. However, RNFL measurements were less consistent. The overall average RNFL thickness was 4 mum greater on the Stratus than on the 3D OCT-1000, which was in turn 5 mum greater than on the Cirrus device. Bland-Altman plots showed poor-to-moderate agreement in terms of macular and RNFL thickness measurements between each 2 of the OCT devices. Both FD OCTs provided more reproducible readings on macular measurements than the Stratus, as evidenced by the lower CV and higher intraclass correlation coefficients. However, RNFL measurements on the 2 FD OCTs were not necessarily more reproducible than those from the Stratus OCT. CONCLUSION: Thickness measurements are not interchangeable among different OCT devices because of the poor-to-moderate interdevice measurement agreement. FD instruments yield more reproducible macular but not RNFL thickness measurements.
机译:目的:使用时域光学相干断层扫描(TD OCT)和2个傅里叶域OCT(FD OCT)比较视网膜神经纤维层(RNFL)和黄斑厚度。方法:对60名正常参与者的60只眼睛进行了眼科检查,然后使用时域Stratus OCT(加利福尼亚州都柏林的卡尔蔡司Meditec公司)和2个FD OCT进行了OCT评估,即Cirrus HD-OCT(卡尔蔡司Meditec公司)。加利福尼亚都柏林)和3D OCT-1000(日本日本东京的拓普康公司)。每位患者由同一位医师检查员在每台机器上扫描3次。使用重复测量方差分析(ANOVA)和使用Bonferroni调整的多重比较t检验,比较了这3种设备的RNFL和黄斑厚度测量值。计算变异系数(CV)和类内相关系数以评估可重复性。构造了Bland-Altman图以评估每2个OCT之间的一致性水平。结果:所有3台机器显示RNFL和黄斑厚度区域差异的相似模式。黄斑厚度在Cirrus上始终最大,在Stratus装置上最低。但是,RNFL测量的一致性较差。 Stratus的整体平均RNFL厚度比3D OCT-1000大4微米,而3D OCT-1000又比Cirrus装置大5微米。在每2个OCT设备之间的黄斑和RNFL厚度测量方面,Bland-Altman图显示了差到中度的一致性。与较低的CV和较高的组内相关系数相比,这两种FD OCT在黄斑测量方面均提供了比Stratus更可再现的读数。但是,在2个FD OCT上进行的RNFL测量结果不一定比Stratus OCT的再现性更高。结论:由于器件间的测量协议差到中等,因此厚度测量不能在不同的OCT器件之间互换。 FD仪器产生的黄斑重现性更高,但RNFL厚度测量却没有。

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