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首页> 外文期刊>Journal of glaucoma >Effect of topical tafluprost on optic nerve head blood flow in patients with myopic disc type
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Effect of topical tafluprost on optic nerve head blood flow in patients with myopic disc type

机译：塔弗前列素对近视性视盘型患者视神经乳头血流的影响

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Purpose: To investigate the effect of topical tafluprost on optic disc blood flow in patients with myopic disc. Materials and Methods: Forty-eight eyes in 24 patients with a myopic disc type (oval shaped) optic disc tilted to the temporal, with a crescent peripapillary atrophy were included in this study. Twenty-eight eyes were diagnosed as normal tension glaucoma and 20 eyes were in normal subjects. None had any treatment for glaucoma. Average age was 45.3±11.9 years. One eye was treated with topical tafluprost and the fellow eye served as the control. Ocular blood flow was measured by laser speckle flowgraphy (LSFG-NAVI) at 30, 60, 90, and 120 minutes after tafluprost administration, and the mean blur rate (MBR) on the optic disc was analyzed. Blood pressure and intraocular pressure (IOP) were recorded. Results: In all subjects, topical tafluprost (a) significantly reduced IOP versus baseline from 60 minutes after treatment (baseline: 15.2±3.4mm Hg, 60min: 13.3±3.2mm Hg, P=0.001, 90min: 13.3±3.6mm Hg, P=0.002, 120 min: 13.7±3.4mm Hg, P=0.007); and (b) significantly increased the MBR versus baseline (60min: +4.3±6.6%, P=0.008, 90min: +5.0±4.9%, P<0.001, 120min: +6.7±7.0%, P<0.001). Conclusions: Topical tafluprost increased MBR in the optic nerve head and significantly reduced IOP, effects that may represent beneficial treatment for glaucoma patients with a myopic disc type.
机译：目的：探讨局部用他氟前列素对近视性视盘患者视盘血流的影响。材料与方法：本研究包括24例近视眼盘型（卵形）视盘向颞侧倾斜，月牙周围乳头萎缩的患者的48只眼。诊断为正常眼压性青光眼的有28只眼，正常受试者中有20只眼。没有人对青光眼有任何治疗方法。平均年龄为45.3±11.9岁。一只眼用他氟前列素局部治疗，另一只眼作为对照。 tafluprost给药后30、60、90和120分钟，通过激光散斑成像（LSFG-NAVI）测量眼部血流，并分析视盘上的平均模糊率（MBR）。记录血压和眼内压（IOP）。结果：在所有受试者中，局部tafluprost（a）自治疗后60分钟以来均较基线水平显着降低了IOP（基线：15.2±3.4mm Hg，60min：13.3±3.2mm Hg，P = 0.001，90min：13.3±3.6mm Hg， P = 0.002，120分钟：13.7±3.4mm Hg，P = 0.007）; （b）与基线相比，MBR显着增加（60分钟：+ 4.3±6.6％，P = 0.008，90分钟：+ 5.0±4.9％，P <0.001，120分钟：+ 6.7±7.0％，P <0.001）。结论：局部使用他氟前列素可增加视神经乳头中的MBR并显着降低IOP，这种作用可能代表对患有近视性视盘型青光眼患者的有益治疗。

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