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首页> 外文期刊>Journal of gastroenterology >Nonalcoholic fatty liver disease in Japanese patients with severe obesity who received laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) in comparison to non-Japanese patients.
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Nonalcoholic fatty liver disease in Japanese patients with severe obesity who received laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) in comparison to non-Japanese patients.

机译：与非日本人患者相比，接受腹腔镜Roux-en-Y胃搭桥手术（LRYGB）的日本严重肥胖患者的非酒精性脂肪肝疾病。

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BACKGROUND: The number of patients with morbid obesity is increasing worldwide. However, the prevalence of morbid obesity is still low in Japan, and therefore few systematic investigations of liver dysfunction in this population have so far been carried out. This study aimed to investigate the clinical characteristics in severe obese Japanese patients undergoing laparoscopic Roux-en-Y gastric bypass surgery (LRYGB). METHODS: Eighty-four patients with severe obesity, including 61 Japanese and 23 non-Japanese patients, were analyzed. RESULTS: The mean body mass index (BMI) was 43.7 +/- 7.8 kg/m(2), and there was no difference between Japanese and non-Japanese patients. Nonalcoholic fatty liver disease (NAFLD) was observed in 45/59 (76.2%) of the Japanese patients. Although there were no differences in the BMI and body weight, serum ALT was higher in Japanese patients in comparison to non-Japanese patients (P < 0.05). The indices for insulin resistance were significantly higher in the Japanese patients incomparison to non-Japanese patients (P < 0.01). The liver/spleen computed tomography (CT) ratios were lower in Japanese patients (P < 0.05). The laboratory data and BMI significantly improved at 1 year after LRYGB in both groups. CONCLUSIONS: Racial difference may exist difference may exist in NAFLD in patients with severe obesity. When the BMI is similar, liver dysfunction among Japanese patients with severe obesity tends to be higher than in non-Japanese patients. Japanese patients with severe obesity must therefore reduce their body weight to a greater degree in comparison to non-Japanese patients with the same BMI. LRYGB can achieve effective weight control and lower ALT levels in Japanese patients with severe obesity.
机译：背景：世界范围内病态肥胖的患者人数正在增加。但是，在日本，病态肥胖的患病率仍然很低，因此迄今为止，对该人群肝功能障碍的系统研究很少。这项研究旨在调查接受腹腔镜Roux-en-Y胃搭桥手术（LRYGB）的日本重症肥胖患者的临床特征。方法：分析了84名严重肥胖患者，包括61名日本人和23名非日本人患者。结果：平均体重指数（BMI）为43.7 +/- 7.8 kg / m（2），日本人和非日本人患者之间没有差异。在日本的45/59（76.2％）患者中观察到非酒精性脂肪肝疾病（NAFLD）。尽管BMI和体重没有差异，但日本患者的血清ALT高于非日本患者（P <0.05）。与非日本人相比，日本人胰岛素抵抗指数明显更高（P <0.01）。日本患者的肝/脾计算机断层扫描（CT）比率较低（P <0.05）。两组在LRYGB后1年的实验室数据和BMI均显着改善。结论：重度肥胖患者NAFLD可能存在种族差异。当BMI相似时，严重肥胖的日本患者中的肝功能障碍往往高于非日本患者。因此，与具有相同BMI的非日本患者相比，严重肥胖的日本患者必须更大程度地减轻体重。 LRYGB可在日本严重肥胖的患者中实现有效的体重控制并降低ALT水平。

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