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首页> 外文期刊>Journal of gastroenterology and hepatology >Psychometric Hepatic Encephalopathy Score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis
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Psychometric Hepatic Encephalopathy Score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis

机译：心理计量学肝性脑病评分用于检测韩国肝硬化患者的最小型肝性脑病

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Background and Aim: Although the Psychometric Hepatic Encephalopathy Score (PHES) for the diagnosis of minimal hepatic encephalopathy (MHE) has been validated in several countries, further validation is required for its use in different populations. The aims of this study were thus to standardize the PHES in a healthy Korean population and evaluate the prevalence of MHE among Korean patients with liver cirrhosis. Methods: Two-hundred healthy subjects without evidence of liver disease and 160 patients with liver cirrhosis without overt HE were included. Blood sampling for routine laboratory tests and determination of venous ammonia concentration was performed on the day of PHES neuropsychological testing. Results: The age and education years of the control group were 41±13years and 13±3years, respectively; 100 of the subjects (50.0%) were men. The PHES for the control group was -0.31±2.06 and the normal range was thus set at >-5 points. The age and education years of the liver cirrhosis group were 55±8 and 11±4years, respectively; 102 of those in this group (63.8%) were men. Of the liver cirrhosis patients, 129 (80.6%), 21 (13.1%), and 10 (6.3%) had Child-Pugh grades A, B, and C, respectively. The PHES of the liver cirrhosis group was -2.94±3.39. MHE was diagnosed in 41 patients (25.6%), of which 26 (20.2%), nine (42.9%), and six (60.0%) had Child-Pugh grades A, B, and C, respectively. Conclusions: The PHES was useful for detecting patients with MHE. A significant proportion of Korean patients with liver cirrhosis suffer from MHE.
机译：背景与目的：尽管已在一些国家对用于诊断最小型肝性脑病（MHE）的心理肝性脑病评分（PHES）进行了验证，但仍需要对其进行进一步的验证才能在不同人群中使用。因此，本研究的目的是标准化健康韩国人口中的PHES，并评估韩国肝硬化患者中MHE的患病率。方法：纳入200例无肝病证据的健康受试者和160例无明显HE的肝硬化患者。在PHES神经心理学测试当天，进行了常规实验室检查的血液采样和静脉氨浓度的测定。结果：对照组年龄和受教育年限分别为41±13岁和13±3岁。 100名受试者（50.0％）是男性。对照组的PHES为-0.31±2.06，因此正常范围设置为> -5点。肝硬化组的年龄和受教育年限分别为55±8岁和11±4岁。该组中的102名（63.8％）是男性。在肝硬化患者中，分别有Child-Pugh等级A，B和C的分别为129名（80.6％），21名（13.1％）和10名（6.3％）。肝硬化组的PHES为-2.94±3.39。已诊断出41例（25.6％）MHE，其中Child-Pugh分别为A，B和C级的患者为26（20.2％），9（42.9％）和6（60.0％）。结论：PHES可用于检测MHE患者。韩国肝硬化患者中有很大一部分患有MHE。

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