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首页> 外文期刊>Journal of gastroenterology and hepatology >'Normal' liver stiffness values differ between men and women: A prospective study for healthy living liver and kidney donors in a native Korean population
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'Normal' liver stiffness values differ between men and women: A prospective study for healthy living liver and kidney donors in a native Korean population

机译：男性和女性的“正常”肝硬度值不同：一项针对韩国原住民健康活体肝脏和肾脏供体的前瞻性研究

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Background and Aim: Liver stiffness (LS) measurement can distinguish individuals with potential liver disease (LD) from the general population. However, if LS is sex-sensitive, prevalence of LD may be incorrectly estimated when the same reference LS value is applied irrespective of sex. Here, we evaluated whether normal ranges of LS differ between healthy men and women. Methods: LS was measured in a cohort of healthy living liver and kidney donors, none of whom suffered from diabetes mellitus, hypertension, hepatitis B or C virus infection, heart or liver dysfunction, or metabolic syndrome. Patients with abnormal laboratory findings related to potential LD (platelet count<150×10 3/μL; aspartate aminotransferase>40IU/L; alanine aminotransferase [ALT]>40IU/L; albumin<3.3g/dL; total bilirubin>1.2mg/dL; gamma-glutamyl transpeptidase>54IU/L; alkaline phosphatase>115IU/L) were excluded. Results: Among 242 patients analyzed, the mean age was 34.1 for men (n=121) and 40.5years for women (n=121) (P<0.001). Men had a higher mean LS value than women (5.2±1.2 vs 4.8±1.1kPa/P<0.001). Multivariate-linear regression analysis identified sex as the only independent factor for LS values (β=0.361/P=0.021). Using the 5th-95th percentiles, we determined normal LS ranges of 3.7-7.0kPa in men and 3.3-6.8kPa in women. In subgroups with ALT<30IU/L (subgroup-1, n=216) and ALT<20IU/L (subgroup-2, n=163), men had significantly higher LS values than women (5.2±1.3 vs 4.7±1.1kPa/P=0.003 and 5.1±1.2 vs 4.7±1.1kPa/P=0.030, respectively), demonstrating an independent sex effect (β=0.483/P=0.003 and β=0.389/P=0.030, respectively). Conclusions: An independent sex effect on LS values was confirmed. Thus, sex-specific references should be used for effective screening based on LS measurements.
机译：背景与目的：肝硬度（LS）的测量可以区分具有潜在肝病（LD）的人群和一般人群。但是，如果LS对性别敏感，则当应用相同的参考LS值而与性别无关时，可能会错误地估计LD的患病率。在这里，我们评估了健康男性和女性的LS正常范围是否存在差异。方法：在一群健康的活体肝脏和肾脏供体中测量了LS，这些患者均未患有糖尿病，高血压，乙型或丙型肝炎病毒感染，心脏或肝脏功能障碍或代谢综合征。实验室检查结果异常与潜在LD相关的患者（血小板计数<150×10 3 /μL;天冬氨酸转氨酶> 40IU / L;丙氨酸转氨酶[ALT]> 40IU / L;白蛋白<3.3g / dL;总胆红素> 1.2mg / L排除dL;γ-谷氨酰转肽酶> 54IU / L;碱性磷酸酶> 115IU / L）。结果：在分析的242例患者中，男性的平均年龄为34.1岁（n = 121），女性的平均年龄为40.5岁（n = 121）（P <0.001）。男性的平均LS值高于女性（5.2±1.2 vs 4.8±1.1kPa / P <0.001）。多元线性回归分析确定性别是LS值的唯一独立因素（β= 0.361 / P = 0.021）。使用第5至95个百分位数，我们确定了男性的正常LS范围为3.7-7.0kPa，女性为3.3-6.8kPa。在ALT <30IU / L（亚组1，n = 216）和ALT <20IU / L（亚组2，n = 163）的亚组中，男性的LS值明显高于女性（5.2±1.3 vs 4.7±1.1kPa） /P=0.003和5.1±1.2相对于4.7±1.1kPa / P = 0.030），显示出独立的性别效应（分别为β= 0.483 / P = 0.003和β= 0.389 / P = 0.030）。结论：证实了对LS值的独立性别影响。因此，基于LS测量值，应使用针对性别的参考进行有效筛查。

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