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首页> 外文期刊>Journal of hepato-biliary-pancreatic surgery >A minute nonfunctioning islet cell tumor demonstrating malignant features.
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A minute nonfunctioning islet cell tumor demonstrating malignant features.

机译：微小的无功能胰岛细胞肿瘤表现出恶性特征。

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摘要

We report a patient with a minute nonfunctioning islet cell tumor, 8 mm in diameter, which demonstrated malignant features by histology. The patient was a 43-year-old Japanese woman, who had an elevated carbohydrate antigen (CA) 19-9 level, of 59 U/ml (normal range, <37 U/ml) identified on a health check to rule out malignancies. Ultrasonography and computed tomography demonstrated a well-defined pancreatic tumor, 8 mm in diameter, in the body of the pancreas. Serum levels of pancreatic hormones were within normal limits, and thus a tentative diagnosis was nonfunctioning islet cell tumor. The size of the tumor remained unchanged for 1 1/2 years, but, at this time, the serum level of CA19-9 was elevated to 253 U/ml. Segmental pancreatectomy was performed because malignancy could not be ruled out. The resected specimen showed an endocrine tumor invading both the pancreatic parenchyma and the perineural spaces outside the tumor. In general, minute nonfunctioning islet cell tumors have been considered to be completely benign, but the present tumor showed clear malignant features. We might have to take surgical resection into consideration even if the size of such an endocrine tumor is minute.
机译：我们报告了一个患者，它有一个微小的无功能的胰岛细胞瘤，直径为8毫米，通过组织学表现出恶性特征。患者是一名43岁的日本女性，通过健康检查可以排除恶性肿瘤，其碳水化合物抗原（CA）19-9水平升高，为59 U / ml（正常范围，<37 U / ml）。 。超声检查和计算机断层扫描显示胰腺体内直径8毫米的明确的胰腺肿瘤。胰激素的血清水平在正常范围内，因此初步诊断为胰岛细胞瘤无功能。肿瘤的大小在1 1/2年内保持不变，但是此时，CA19-9的血清水平升高至253 U / ml。因为不能排除恶性肿瘤，所以进行了节段性胰腺切除术。切除的标本显示内分泌肿瘤侵犯胰腺实质和肿瘤外的神经周围间隙。通常，微小的无功能的胰岛细胞瘤被认为是完全良性的，但是目前的肿瘤表现出明显的恶性特征。即使这种内分泌肿瘤的大小很小，我们也可能必须考虑手术切除。

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