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首页> 外文期刊>Journal of hypertension >Effects of antihypertensive agents, alpha receptor blockers, beta blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and calcium channel blockers, on oxidative stress.
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Effects of antihypertensive agents, alpha receptor blockers, beta blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and calcium channel blockers, on oxidative stress.

机译：抗高血压药，α受体阻滞剂，β受体阻滞剂，血管紧张素转化酶抑制剂，血管紧张素受体阻滞剂和钙通道阻滞剂对氧化应激的影响。

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BACKGROUNDFree oxygen radicals and insufficiency of antioxidant enzymes have been implicated in the pathogenesis of hypertension disease (HD). Trace elements function as a co-factor in antioxidant enzymes. The antioxidant system and trace elements have been investigated in many different studies including HD, but these subjects have not been investigated as a whole in these patients.OBJECTIVEThe aim of the present study was to investigate the antioxidative system and trace elements in hypertensive patients given different antihypertensive therapy.METHODSWe examined malondialdehyde and superoxide dismutase activities together with copper and zinc levels in plasma of 102 patients with HD and in 51 healthy controls.RESULTSIt was found that in patients with HD, plasma malondialdehyde was significantly higher than those of controls, while plasma superoxide dismutase activities were significantly lower in patients with HD. Plasma zinc levels were significantly higher than those of controls and plasma copper levels were significantly lower in patients with HD. Plasma lipid levels and oxidative state were analyzed in five different treatment groups given antihypertensive drug therapy before and after a 3-month treatment period.CONCLUSIONSIn conclusion, our clinical study shows that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have notable effects on oxidative stress, and are an essential step in managing essential hypertension by the way of improvement of endothelial dysfunction. Although it has been shown that calcium channel blockers, beta blockers and alpha receptor blockers have antioxidant effects in in vitro conditions, we did not demonstrate these effects in our clinical study.
机译：背景技术游离氧自由基和抗氧化酶不足已被认为与高血压疾病（HD）的发病机理有关。微量元素是抗氧化酶的辅助因子。抗氧化剂系统和微量元素已在包括HD在内的许多不同研究中进行了研究，但尚未对这些患者进行整体研究。目的本研究的目的是研究高血压患者中不同抗氧化剂系统和微量元素的差异。方法我们检测了102名HD患者和51名健康对照者血浆中的丙二醛和超氧化物歧化酶活性以及铜和锌水平。结果发现，HD患者血浆中的丙二醛水平明显高于对照者，而血浆中HD患者的超氧化物歧化酶活性显着降低。 HD患者血浆锌水平显着高于对照组，血浆铜水平显着降低。在为期3个月的治疗前后，对五个不同的治疗组进行了降压药物治疗，分析了血浆脂质水平和氧化状态。结论总之，我们的临床研究表明血管紧张素转化酶抑制剂和血管紧张素受体阻滞剂对氧化应激有显着影响是通过改善内皮功能障碍来控制原发性高血压的重要步骤。尽管已显示钙通道阻滞剂，β阻滞剂和α受体阻滞剂在体外条件下具有抗氧化作用，但我们在临床研究中并未证明这些作用。

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