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首页> 外文期刊>Journal of hypertension >Ambulatory blood pressure, target organ damage and left atrial size in never-treated essential hypertensive individuals.
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Ambulatory blood pressure, target organ damage and left atrial size in never-treated essential hypertensive individuals.

机译：未经治疗的原发性高血压患者的动态血压，靶器官损害和左心房大小。

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OBJECTIVE: To investigate the relationship between ambulatory blood pressure and different markers of target organ damage with left atrial size in never-treated essential hypertensive individuals. METHODS: A total of 519 grade 1 and 2 hypertensive patients (mean age 46 +/- 12 years), referred for the first time to our outpatient clinic, underwent routine examinations: 24-h urine collection for microalbuminuria, ambulatory blood pressure monitoring over two 24-h periods in 4 weeks, echocardiography and carotid ultrasonography. RESULTS: Left atrial diameter was increased in 17.3% of patients. No significant differences were found between subjects with and without increased left atrial size with regard to sex, duration of hypertension, clinic and mean 48-h ambulatory blood pressure, and daytime and night-time values. Compared with 429 patients with normal left atrial size, the 90 patients with enlarged left atria were older, had higher body mass index, were more frequently smokers, and included more individuals with the metabolic syndrome. The prevalence of left ventricular hypertrophy, of intima-media thickening, but not of microalbuminuria was significantly higher in subjects with increased left atrial size. CONCLUSION: Left atrial enlargement is not an early echocardiographic finding in relatively young never-treated hypertensive individuals, as its prevalence is lower than that of well-validated markers of target organ damage, and it is unrelated to ambulatory blood pressure. Overweight, left ventricular hypertrophy, carotid intima-media thickening and metabolic syndrome are independent predictors of left atrial dimension, suggesting that changes in left atrial size represent an adaptive response when high blood pressure is associated with other cardiovascular or metabolic abnormalities.
机译：目的：探讨未经治疗的原发性高血压患者动态血压与靶器官损害的不同标志物与左心房大小之间的关系。方法：共有519名1级和2级高血压患者（平均年龄46 +/- 12岁），首次转诊至我们的门诊，接受了常规检查：24小时尿液收集微量白蛋白尿，动态血压监测在4周内进行两个24小时周期的超声心动图检查和颈动脉超声检查。结果：左心房直径增加了17.3％的患者。在性别，高血压病持续时间，门诊和平均48小时动态血压以及白天和晚上的时间方面，左心房大小是否增加都没有显着差异。与429名左心房大小正常的患者相比，90例左心房增大的患者年龄更大，体重指数更高，吸烟者更频繁并且包括更多的代谢综合征患者。在左心房增大的患者中，左心室肥大，内膜中膜增厚的发生率较高，而微量白蛋白尿的发生率则明显较高。结论：相对未接受治疗的年轻高血压患者，左心房扩大并不是早期的超声心动图检查，因为其患病率低于有效验证的靶器官损害标志物，并且与动态血压无关。超重，左心室肥大，颈动脉内膜中层增厚和代谢综合征是左心房尺寸的独立预测因子，表明当高血压与其他心血管或代谢异常相关时，左心房大小的变化代表了适应性反应。

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